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@article{1380300,
author = {Bernhauerová, Veronika},
article_location = {HEIDELBERG},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s12080-016-0300-5},
keywords = {Age-structured model; Adaptive dynamics; Bordetella pertussis; Immune evasion; Vaccination; Virulence},
language = {eng},
issn = {1874-1738},
journal = {Theoretical Ecology},
title = {Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis},
url = {https://link.springer.com/content/pdf/10.1007/s12080-016-0300-5.pdf},
volume = {9},
year = {2016}
}
TY - JOUR
ID - 1380300
AU - Bernhauerová, Veronika
PY - 2016
TI - Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis
JF - Theoretical Ecology
VL - 9
IS - 4
SP - 431-442
EP - 431-442
PB - SPRINGER HEIDELBERG
SN - 18741738
KW - Age-structured model
KW - Adaptive dynamics
KW - Bordetella pertussis
KW - Immune evasion
KW - Vaccination
KW - Virulence
UR - https://link.springer.com/content/pdf/10.1007/s12080-016-0300-5.pdf
L2 - https://link.springer.com/content/pdf/10.1007/s12080-016-0300-5.pdf
N2 - Despite enormous success of mass immunization programs in reducing incidence of infectious diseases, vaccine-escape strains have emerged perhaps as a consequence of strong selection pressures exerted on parasites by vaccines. Pertussis presents a well-documented example. As a childhood infection, it exhibits age-specific transmission biased to children. Assuming different transmission rates between children and adults, I study, by means of an age-structured epidemic model, evolutionary dynamics of parasite virulence in a vaccinated population. I find that the age-structure does not affect the evolutionary dynamics of parasite virulence. Also, based on empirical data reporting antigenic divergence with vaccine strains and mutations in virulence-associated genes in pertussis populations, I allow for parallel occurrence of mutations in parasite virulence and associated immune evasion. I conclude that this simultaneous adaptation of both traits may substantially alter the evolutionary course of the parasite. In particular, higher values of virulence are favoured once the parasite is able to evade the transmission-blocking vaccine-induced immunity. On the other hand, lower values of virulence are selected for once the parasite evolves the ability to evade the virulence-blocking vaccine-induced immunity. I emphasize the importance of multi-trait evolution to assess the direction of parasite adaptation more accurately.
ER -
BERNHAUEROVÁ, Veronika. Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis. \textit{Theoretical Ecology}. HEIDELBERG: SPRINGER HEIDELBERG, 2016, vol.~9, No~4, p.~431-442. ISSN~1874-1738. Available from: https://dx.doi.org/10.1007/s12080-016-0300-5.
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