J 2016

Reprint of "DNA, the central molecule of aging"

LENÁRT, Peter and Lumír KREJČÍ

Basic information

Original name

Reprint of "DNA, the central molecule of aging"

Authors

LENÁRT, Peter (703 Slovakia, belonging to the institution) and Lumír KREJČÍ (203 Czech Republic, belonging to the institution)

Edition

Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis, Amsterdam, Elsevier Science BV, 2016, 0027-5107

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.829

RIV identification code

RIV/00216224:14310/16:00094241

Organization unit

Faculty of Science

DOI

UT WoS

000378182200006

Keywords in English

DNA; Aging; Chromatin structure; Telomeres; DNA damage; DNA repair; Mutagenesis

Tags

Změněno: 11/5/2017 18:24, Ing. Andrea Mikešková

Abstract

V originále

Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes. (C) 2016 Published by Elsevier B.V.

Links

GA13-26629S, research and development project
Name: SUMO a stability genomu
Investor: Czech Science Foundation