Reprint of "DNA, the central molecule of aging"

LENÁRT, Peter and Lumír KREJČÍ. Reprint of "DNA, the central molecule of aging". Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier Science BV, vol. 788, June, p. 25-31. ISSN 0027-5107. doi:10.1016/j.mrfmmm.2016.04.002. 2016.

Basic information

• Original name: Reprint of "DNA, the central molecule of aging"
• Authors: LENÁRT, Peter (703 Slovakia, belonging to the institution) and Lumír KREJČÍ (203 Czech Republic, belonging to the institution).
• Edition: Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis, Amsterdam, Elsevier Science BV, 2016, 0027-5107.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.829
• RIV identification code: RIV/00216224:14310/16:00094241
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1016/j.mrfmmm.2016.04.002
• UT WoS: 000378182200006
• Keywords in English: DNA; Aging; Chromatin structure; Telomeres; DNA damage; DNA repair; Mutagenesis
• Tags: AKR, rivok

Abstract

Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes. (C) 2016 Published by Elsevier B.V.

Links

• GA13-26629S, research and development project: Name: SUMO a stability genomu

Investor: Czech Science Foundation