Biological plausibility as a tool to associate analytical data
for micropollutants and effect potentials in wastewater,
surface water, and sediments with effects in fishes

J 2015

Biological plausibility as a tool to associate analytical data for micropollutants and effect potentials in wastewater, surface water, and sediments with effects in fishes

MAIER, Diana, Luděk BLÁHA, John P. GIESY, Anja HENNEBERG, Heinz R. KOHLER et. al.

Basic information

Original name

Biological plausibility as a tool to associate analytical data for micropollutants and effect potentials in wastewater, surface water, and sediments with effects in fishes

Authors

MAIER, Diana (276 Germany), Luděk BLÁHA (203 Czech Republic, belonging to the institution), John P. GIESY (124 Canada), Anja HENNEBERG (276 Germany), Heinz R. KOHLER (276 Germany), Bertram KUCH (276 Germany), Raphaela OSTERAUER (276 Germany), Katharina PESCHKE (276 Germany), Doreen RICHTER (276 Germany), Marco SCHEURER (276 Germany) and Rita TRIEBSKORN (276 Germany)

Edition

Water Research, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2015, 0043-1354

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.991

RIV identification code

RIV/00216224:14310/15:00094263

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.watres.2014.08.050

UT WoS

000353605000008

Keywords in English

Dioxin-like toxicity; Genotoxicity; Embryotoxicity; Fish health; Biotests; Biomarkers

Abstract

V originále

Discharge of substances like pesticides, pharmaceuticals, flame retardants, and chelating agents in surface waters has increased over the last decades due to the rising numbers of chemicals used by humans and because many WWTPs do not eliminate these substances entirely. The study, results of which are presented here, focused on associations of (1) concentrations of micropollutants in wastewater treatment plant (WWTP) effluents, surface waters, sediments, and tissues of fishes; (2) results of laboratory biotests indicating potentials for effects in these samples and (3) effects either in feral chub (Leuciscus cephalus) from two German rivers (Schussen, Argen) or in brown trout (Salmo trutta f. fario) and rainbow trout (Oncorhynchus mykiss) exposed in bypass systems to streamwater of these rivers or in cages directly in the rivers. The Schussen and Argen Rivers flow into Lake Constance. The Schussen River is polluted by a great number of chemicals, while the Argen River is less influenced by micropollutants. Pesticides, chelating agents, flame retardants, pharmaceuticals, heavy metals, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) were detected in effluents of a WWTP discharging to the Schussen as well as in surface water, and/or fishes from downstream of the WWTP. Results obtained by biotests conducted in the laboratory (genotoxicity, dioxin-like toxicity, and embryotoxicity) were linked to effects in feral fish collected in the vicinity of the WWTP or in fishes exposed in cages or at the bypass systems downstream of the WWTP. Dioxin-like effect potentials detected by reporter gene assays were associated with activation of CYP1A1 enzymes in fishes which are inducible by dioxin-like chemicals. Abundances of several PCBs in tissues of fishes from cages and bypass systems were not associated with these effects but other factors can influence EROD activity. Genotoxic potentials obtained by in vitro tests were associated with the presence of micronuclei in erythrocytes of chub from the river. Chemicals potentially responsible for effects on DNA were identified. Embryotoxic effects on zebrafish (Dania rerio), investigated in the laboratory, were associated with embryotoxic effects in trout exposed in streamwater bypass systems at the two rivers. In general, responses at all levels of organization were more pronounced in samples from the Schussen than in those from the Argen. These results are consistent with the magnitudes of chemical pollution in these two streams. Plausibility chains to establish causality between exposures and effects and to predict effects in biota in the river from studies in the laboratory are discussed. (C) 2014 Elsevier Ltd. All rights reserved.

Citovat

MAIER, Diana, Luděk BLÁHA, John P. GIESY, Anja HENNEBERG, Heinz R. KOHLER, Bertram KUCH, Raphaela OSTERAUER, Katharina PESCHKE, Doreen RICHTER, Marco SCHEURER and Rita TRIEBSKORN. Biological plausibility as a tool to associate analytical data for micropollutants and effect potentials in wastewater, surface water, and sediments with effects in fishes. Water Research. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2015, vol. 72, April, p. 127-144. ISSN 0043-1354. Available from: https://dx.doi.org/10.1016/j.watres.2014.08.050.

@article{1380334,
   author = {Maier, Diana and Bláha, Luděk and Giesy, John P. and Henneberg, Anja and Kohler, Heinz R. and Kuch, Bertram and Osterauer, Raphaela and Peschke, Katharina and Richter, Doreen and Scheurer, Marco and Triebskorn, Rita},
   article_location = {OXFORD},
   article_number = {April},
   doi = {http://dx.doi.org/10.1016/j.watres.2014.08.050},
   keywords = {Dioxin-like toxicity; Genotoxicity; Embryotoxicity; Fish health; Biotests; Biomarkers},
   language = {eng},
   issn = {0043-1354},
   journal = {Water Research},
   title = {Biological plausibility as a tool to associate analytical data for micropollutants and effect potentials in wastewater, surface water, and sediments with effects in fishes},
   volume = {72},
   year = {2015}
}

TY  - JOUR
ID  - 1380334
AU  - Maier, Diana - Bláha, Luděk - Giesy, John P. - Henneberg, Anja - Kohler, Heinz R. - Kuch, Bertram - Osterauer, Raphaela - Peschke, Katharina - Richter, Doreen - Scheurer, Marco - Triebskorn, Rita
PY  - 2015
TI  - Biological plausibility as a tool to associate analytical data for micropollutants and effect potentials in wastewater, surface water, and sediments with effects in fishes
JF  - Water Research
VL  - 72
IS  - April
SP  - 127-144
EP  - 127-144
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 00431354
KW  - Dioxin-like toxicity
KW  - Genotoxicity
KW  - Embryotoxicity
KW  - Fish health
KW  - Biotests
KW  - Biomarkers
N2  - Discharge of substances like pesticides, pharmaceuticals, flame retardants, and chelating agents in surface waters has increased over the last decades due to the rising numbers of chemicals used by humans and because many WWTPs do not eliminate these substances entirely. The study, results of which are presented here, focused on associations of (1) concentrations of micropollutants in wastewater treatment plant (WWTP) effluents, surface waters, sediments, and tissues of fishes; (2) results of laboratory biotests indicating potentials for effects in these samples and (3) effects either in feral chub (Leuciscus cephalus) from two German rivers (Schussen, Argen) or in brown trout (Salmo trutta f. fario) and rainbow trout (Oncorhynchus mykiss) exposed in bypass systems to streamwater of these rivers or in cages directly in the rivers. The Schussen and Argen Rivers flow into Lake Constance. The Schussen River is polluted by a great number of chemicals, while the Argen River is less influenced by micropollutants. Pesticides, chelating agents, flame retardants, pharmaceuticals, heavy metals, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) were detected in effluents of a WWTP discharging to the Schussen as well as in surface water, and/or fishes from downstream of the WWTP. Results obtained by biotests conducted in the laboratory (genotoxicity, dioxin-like toxicity, and embryotoxicity) were linked to effects in feral fish collected in the vicinity of the WWTP or in fishes exposed in cages or at the bypass systems downstream of the WWTP. Dioxin-like effect potentials detected by reporter gene assays were associated with activation of CYP1A1 enzymes in fishes which are inducible by dioxin-like chemicals. Abundances of several PCBs in tissues of fishes from cages and bypass systems were not associated with these effects but other factors can influence EROD activity. Genotoxic potentials obtained by in vitro tests were associated with the presence of micronuclei in erythrocytes of chub from the river. Chemicals potentially responsible for effects on DNA were identified. Embryotoxic effects on zebrafish (Dania rerio), investigated in the laboratory, were associated with embryotoxic effects in trout exposed in streamwater bypass systems at the two rivers. In general, responses at all levels of organization were more pronounced in samples from the Schussen than in those from the Argen. These results are consistent with the magnitudes of chemical pollution in these two streams. Plausibility chains to establish causality between exposures and effects and to predict effects in biota in the river from studies in the laboratory are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
ER  -

MAIER, Diana, Luděk BLÁHA, John P. GIESY, Anja HENNEBERG, Heinz R. KOHLER, Bertram KUCH, Raphaela OSTERAUER, Katharina PESCHKE, Doreen RICHTER, Marco SCHEURER and Rita TRIEBSKORN. Biological plausibility as a tool to associate analytical data for micropollutants and effect potentials in wastewater, surface water, and sediments with effects in fishes. \textit{Water Research}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2015, vol.~72, April, p.~127-144. ISSN~0043-1354. Available from: https://dx.doi.org/10.1016/j.watres.2014.08.050.

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