Oriented clonal cell dynamics enables accurate growth and
shaping of vertebrate cartilage

J 2017

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

KAUCKA, Marketa, Tomas ZIKMUND, Marketa TESAROVA, Daniel GYLLBORG, Andreas HELLANDER et. al.

Basic information

Original name

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

Authors

KAUCKA, Marketa (752 Sweden), Tomas ZIKMUND (203 Czech Republic), Marketa TESAROVA (203 Czech Republic), Daniel GYLLBORG (752 Sweden), Andreas HELLANDER (752 Sweden), Josef JAROŠ (203 Czech Republic, belonging to the institution), Jozef KAISER (203 Czech Republic), Julian PETERSEN (40 Austria), Bara SZAROWSKA (40 Austria), Phillip T. NEWTON (752 Sweden), Vyacheslav DYACHUK (752 Sweden), Lei LI (752 Sweden), Hong QIAN (752 Sweden), Anne-Sofie JOHANSSON (752 Sweden), Yuji MISHINA (840 United States of America), Joshua D CURRIE (276 Germany), Elly M TANAKA (276 Germany), Alek ERICKSON (840 United States of America), Andrew DUDLEY (840 United States of America), Hjalmar BRISMAR (752 Sweden), Paul SOUTHAM (826 United Kingdom of Great Britain and Northern Ireland), Enrico COEN (826 United Kingdom of Great Britain and Northern Ireland), Min CHEN (840 United States of America), Lee S WEINSTEIN (840 United States of America), Aleš HAMPL (203 Czech Republic, guarantor, belonging to the institution), Ernest ARENAS (752 Sweden), Andrei S CHAGIN (752 Sweden), Kaj FRIED (752 Sweden) and Igor ADAMEYKO (752 Sweden)

Edition

eLife, Cambridge, eLife Sciences Publications Ltd. 2017, 2050-084X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 7.616

RIV identification code

RIV/00216224:14110/17:00096667

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.7554/eLife.25902

UT WoS

000400576600001

Keywords in English

Cartilaginous structures

Abstract

V originále

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Citovat

KAUCKA, Marketa, Tomas ZIKMUND, Marketa TESAROVA, Daniel GYLLBORG, Andreas HELLANDER, Josef JAROŠ, Jozef KAISER, Julian PETERSEN, Bara SZAROWSKA, Phillip T. NEWTON, Vyacheslav DYACHUK, Lei LI, Hong QIAN, Anne-Sofie JOHANSSON, Yuji MISHINA, Joshua D CURRIE, Elly M TANAKA, Alek ERICKSON, Andrew DUDLEY, Hjalmar BRISMAR, Paul SOUTHAM, Enrico COEN, Min CHEN, Lee S WEINSTEIN, Aleš HAMPL, Ernest ARENAS, Andrei S CHAGIN, Kaj FRIED and Igor ADAMEYKO. Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage. eLife. Cambridge: eLife Sciences Publications Ltd., 2017, vol. 6, e25902, p. 1-37. ISSN 2050-084X. Available from: https://dx.doi.org/10.7554/eLife.25902.

@article{1380622,
   author = {Kaucka, Marketa and Zikmund, Tomas and Tesarova, Marketa and Gyllborg, Daniel and Hellander, Andreas and Jaroš, Josef and Kaiser, Jozef and Petersen, Julian and Szarowska, Bara and Newton, Phillip T. and Dyachuk, Vyacheslav and Li, Lei and Qian, Hong and Johansson, AnneandSofie and Mishina, Yuji and Currie, Joshua D and Tanaka, Elly M and Erickson, Alek and Dudley, Andrew and Brismar, Hjalmar and Southam, Paul and Coen, Enrico and Chen, Min and Weinstein, Lee S and Hampl, Aleš and Arenas, Ernest and Chagin, Andrei S and Fried, Kaj and Adameyko, Igor},
   article_location = {Cambridge},
   article_number = {e25902},
   doi = {http://dx.doi.org/10.7554/eLife.25902},
   keywords = {Cartilaginous structures},
   language = {eng},
   issn = {2050-084X},
   journal = {eLife},
   title = {Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage},
   volume = {6},
   year = {2017}
}

TY  - JOUR
ID  - 1380622
AU  - Kaucka, Marketa - Zikmund, Tomas - Tesarova, Marketa - Gyllborg, Daniel - Hellander, Andreas - Jaroš, Josef - Kaiser, Jozef - Petersen, Julian - Szarowska, Bara - Newton, Phillip T. - Dyachuk, Vyacheslav - Li, Lei - Qian, Hong - Johansson, Anne-Sofie - Mishina, Yuji - Currie, Joshua D - Tanaka, Elly M - Erickson, Alek - Dudley, Andrew - Brismar, Hjalmar - Southam, Paul - Coen, Enrico - Chen, Min - Weinstein, Lee S - Hampl, Aleš - Arenas, Ernest - Chagin, Andrei S - Fried, Kaj - Adameyko, Igor
PY  - 2017
TI  - Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage
JF  - eLife
VL  - 6
IS  - e25902
SP  - 1-37
EP  - 1-37
PB  - eLife Sciences Publications Ltd.
SN  - 2050084X
KW  - Cartilaginous structures
N2  - Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.
ER  -

KAUCKA, Marketa, Tomas ZIKMUND, Marketa TESAROVA, Daniel GYLLBORG, Andreas HELLANDER, Josef JAROŠ, Jozef KAISER, Julian PETERSEN, Bara SZAROWSKA, Phillip T. NEWTON, Vyacheslav DYACHUK, Lei LI, Hong QIAN, Anne-Sofie JOHANSSON, Yuji MISHINA, Joshua D CURRIE, Elly M TANAKA, Alek ERICKSON, Andrew DUDLEY, Hjalmar BRISMAR, Paul SOUTHAM, Enrico COEN, Min CHEN, Lee S WEINSTEIN, Aleš HAMPL, Ernest ARENAS, Andrei S CHAGIN, Kaj FRIED and Igor ADAMEYKO. Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage. \textit{eLife}. Cambridge: eLife Sciences Publications Ltd., 2017, vol.~6, e25902, p.~1-37. ISSN~2050-084X. Available from: https://dx.doi.org/10.7554/eLife.25902.

Detailed Information on Publication Record