| NARDONE, Giorgia, Jorge Oliver-De La CRUZ, Jan VRBSKÝ, Cecilia MARTINI, Jan PŘIBYL, Petr SKLÁDAL, Martin PEŠL, Guido CALUORI, Stefania PAGLIARI, Fabiana MARTINO, Zuzana MACECKOVA, Marian HAJDÚCH, Andres SANZ-GARCIA, Nicola Maria PUGNO, Gorazd Bernard STOKIN and Giancarlo FORTE. YAP regulates cell mechanics by controlling focaladhesion assembly. NATURE COMMUNICATIONS. London: Nature Publishing Group, 2017, vol. 8, No 15321, p. 1-13. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/ncomms15321. |
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@article{1380781,
author = {Nardone, Giorgia and Cruz, Jorge OliverandDe La and Vrbský, Jan and Martini, Cecilia and Přibyl, Jan and Skládal, Petr and Pešl, Martin and Caluori, Guido and Pagliari, Stefania and Martino, Fabiana and Maceckova, Zuzana and Hajdúch, Marian and SanzandGarcia, Andres and Pugno, Nicola Maria and Stokin, Gorazd Bernard and Forte, Giancarlo},
article_location = {London},
article_number = {15321},
doi = {http://dx.doi.org/10.1038/ncomms15321},
keywords = {Hippo effectors YAP/TAZ; mechanosensing; extracellular matrix; focal adhesions; RhoA GTPase activity; actin cytoskeleton},
language = {eng},
issn = {2041-1723},
journal = {NATURE COMMUNICATIONS},
title = {YAP regulates cell mechanics by controlling focaladhesion assembly},
url = {https://www.nature.com/articles/ncomms15321},
volume = {8},
year = {2017}
}
TY - JOUR
ID - 1380781
AU - Nardone, Giorgia - Cruz, Jorge Oliver-De La - Vrbský, Jan - Martini, Cecilia - Přibyl, Jan - Skládal, Petr - Pešl, Martin - Caluori, Guido - Pagliari, Stefania - Martino, Fabiana - Maceckova, Zuzana - Hajdúch, Marian - Sanz-Garcia, Andres - Pugno, Nicola Maria - Stokin, Gorazd Bernard - Forte, Giancarlo
PY - 2017
TI - YAP regulates cell mechanics by controlling focaladhesion assembly
JF - NATURE COMMUNICATIONS
VL - 8
IS - 15321
SP - 1-13
EP - 1-13
PB - Nature Publishing Group
SN - 20411723
KW - Hippo effectors YAP/TAZ
KW - mechanosensing
KW - extracellular matrix
KW - focal adhesions
KW - RhoA GTPase activity
KW - actin cytoskeleton
UR - https://www.nature.com/articles/ncomms15321
L2 - https://www.nature.com/articles/ncomms15321
N2 - Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity control FA formation through YAP to stabilize the anchorage of the actin cytoskeleton to the cell membrane. This mechanism requires YAP co-transcriptional function and involves the activation of genes encoding for integrins and FA docking proteins. Tuning YAP transcriptional activity leads to the modification of cell mechanics, force development and adhesion strength, and determines cell shape, migration and differentiation. These results provide new insights into the mechanism of YAP mechanosensing activity and qualify this Hippo effector as the key determinant of cell mechanics in response to ECM cues.
ER -
NARDONE, Giorgia, Jorge Oliver-De La CRUZ, Jan VRBSKÝ, Cecilia MARTINI, Jan PŘIBYL, Petr SKLÁDAL, Martin PEŠL, Guido CALUORI, Stefania PAGLIARI, Fabiana MARTINO, Zuzana MACECKOVA, Marian HAJDÚCH, Andres SANZ-GARCIA, Nicola Maria PUGNO, Gorazd Bernard STOKIN and Giancarlo FORTE. YAP regulates cell mechanics by controlling focaladhesion assembly. \textit{NATURE COMMUNICATIONS}. London: Nature Publishing Group, 2017, vol.~8, No~15321, p.~1-13. ISSN~2041-1723. Available from: https://dx.doi.org/10.1038/ncomms15321.
|
