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@article{1381311,
author = {Izakovičová Hollá, Lydie and Valová, Simona and Bořilová Linhartová, Petra and Bártová, Jiřina and Petanová, Jitka and Kuklínek, Pavel and Fassmann, Antonín},
article_location = {Hoboken},
article_number = {10},
doi = {http://dx.doi.org/10.1111/jop.12594},
keywords = {IL-1; IL-6; gene polymorphism; aphthous stomatitis; case-control study},
language = {eng},
issn = {0904-2512},
journal = {Journal of Oral Pathology & Medicine},
title = {Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis},
volume = {46},
year = {2017}
}
TY - JOUR
ID - 1381311
AU - Izakovičová Hollá, Lydie - Valová, Simona - Bořilová Linhartová, Petra - Bártová, Jiřina - Petanová, Jitka - Kuklínek, Pavel - Fassmann, Antonín
PY - 2017
TI - Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis
JF - Journal of Oral Pathology & Medicine
VL - 46
IS - 10
SP - 1030-1035
EP - 1030-1035
PB - Wiley
SN - 09042512
KW - IL-1
KW - IL-6
KW - gene polymorphism
KW - aphthous stomatitis
KW - case-control study
N2 - Background Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin 1 (IL-1) and interleukin 6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population. Methods A total of 248 subjects, 184 healthy controls and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTR) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C and IL-6R+48992A>C by polymerase chain reaction (PCR) methods. Results No significant differences between investigated polymorphisms in healthy subjects and patients with RAS were detected (P>0.05). In addition, complex analysis also revealed similar IL-1 or IL-6 haplotype frequencies between both groups (P>0.05). Conclusions In conclusion, IL-1 and IL-6 or its receptor gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.
ER -
IZAKOVIČOVÁ HOLLÁ, Lydie, Simona VALOVÁ, Petra BOŘILOVÁ LINHARTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK a Antonín FASSMANN. Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. \textit{Journal of Oral Pathology \&{} Medicine}. Hoboken: Wiley, roč.~46, č.~10, s.~1030-1035. ISSN~0904-2512. doi:10.1111/jop.12594. 2017.
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