Other formats:
BibTeX
LaTeX
RIS
@article{1381316, author = {Pařenica, Jiří and Jarkovský, Jiří and Maláska, Jan and Mebazaa, Alexandre and Gottwaldová, Jana and Helánová, Kateřina and Litzman, Jiří and Dastych, Milan and Tomandl, Josef and Špinar, Jindřich and Dostálová, Ludmila and Lokaj, Petr and Tomandlová, Marie and Pávková Goldbergová, Monika and Ševčík, Pavel and Legrand, Matthieu}, article_location = {Philadelphia}, article_number = {2}, doi = {http://dx.doi.org/10.1097/SHK.0000000000000756}, keywords = {Cardiogenic shock; C-reactive protein; infection; inflammatory response; pentraxin 3; presepsin; procalcitonin}, language = {eng}, issn = {1073-2322}, journal = {Shock}, title = {Infectious complications and immune/inflammatory response in cardiogenic shock patients: A prospective observational study}, volume = {47}, year = {2017} }
TY - JOUR ID - 1381316 AU - Pařenica, Jiří - Jarkovský, Jiří - Maláska, Jan - Mebazaa, Alexandre - Gottwaldová, Jana - Helánová, Kateřina - Litzman, Jiří - Dastych, Milan - Tomandl, Josef - Špinar, Jindřich - Dostálová, Ludmila - Lokaj, Petr - Tomandlová, Marie - Pávková Goldbergová, Monika - Ševčík, Pavel - Legrand, Matthieu PY - 2017 TI - Infectious complications and immune/inflammatory response in cardiogenic shock patients: A prospective observational study JF - Shock VL - 47 IS - 2 SP - 165-174 EP - 165-174 PB - Lippincott Williams & Wilkins SN - 10732322 KW - Cardiogenic shock KW - C-reactive protein KW - infection KW - inflammatory response KW - pentraxin 3 KW - presepsin KW - procalcitonin N2 - Introduction: Patients with cardiogenic shock (CS) are at a high risk of developing infectious complications; however, their early detection is difficult, mainly due to a frequently occurring noninfectious inflammatory response, which accompanies an extensivemyocardial infarction (MI) or a postcardiac arrest syndrome. The goal of our prospective study was to describe infectious complications in CS and the immune/inflammatory response based on a serial measurement of several blood-based inflammatory biomarkers. Methods: Eighty patients with CS were evaluated and their infections were monitored. Inflammatory markers (C-reactive protein, procalcitonin, pentraxin 3, presepsin) were measured seven times per week. The control groups consisted of 11 patients with ST segment elevation myocardial infarction without CS and without infection, and 22 patients in septic shock. Results: Infection was diagnosed in 46.3% of patients with CS; 16 patients developed an infection within 48 h. Respiratory infection was most common, occurring in 33 out of 37 patients. Infection was a significant or even the main reason of death only in 3.8% of all patients with CS, and we did not find statistically significant difference in 3-month mortality between group of patients with CS with and without infection. There was no statistically significant prolongation of the duration of mechanical ventilation associated with infection. Strong inflammatory response is often in patientswith CS due to MI, but we found no significant difference in the course of the inflammatory response expressed by evaluated biomarkers in patients with CS with and without infection. We found a strong relationship between the elevated inflammatory markers (sampled at 12 h) and the 3-month mortality: the area under the curve of receiver operating characteristic ranged between 0.683 and 0.875. Conclusion: The prevalence of infection in patients with CS was 46.3%, and respiratory tract infections were the most common type. Infections did not prolong statistically significantly the duration of mechanical ventilation and did not increase the prevalence of hospital mortality in this high-risk CS population. CS due to acute myocardial infarction was accompanied by a strong and highly variable inflammatory response, but it did not reach the intensity of the inflammatory response observed in patients with septic shock. An extensive immune/inflammatory response in patients with CS is linked to a poor prognosis. ER -
PAŘENICA, Jiří, Jiří JARKOVSKÝ, Jan MALÁSKA, Alexandre MEBAZAA, Jana GOTTWALDOVÁ, Kateřina HELÁNOVÁ, Jiří LITZMAN, Milan DASTYCH, Josef TOMANDL, Jindřich ŠPINAR, Ludmila DOSTÁLOVÁ, Petr LOKAJ, Marie TOMANDLOVÁ, Monika PÁVKOVÁ GOLDBERGOVÁ, Pavel ŠEVČÍK and Matthieu LEGRAND. Infectious complications and immune/inflammatory response in cardiogenic shock patients: A prospective observational study. \textit{Shock}. Philadelphia: Lippincott Williams \&{} Wilkins, 2017, vol.~47, No~2, p.~165-174. ISSN~1073-2322. Available from: https://dx.doi.org/10.1097/SHK.0000000000000756.
|