| PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří JARKOVSKÝ, Jolana LIPKOVÁ, Simona LITTNEROVÁ, Martin POLOCZEK, Jindřich ŠPINAR, Lenka KUBKOVÁ, Krystyna KLUZ, Petr KALA, Jan MAŇOUŠEK, Anna VAŠKŮ and Jiří PAŘENICA. Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction. Journal of Applied Genetics. Heidelberg: Springer, 2017, vol. 58, No 3, p. 331-341. ISSN 1234-1983. Available from: https://dx.doi.org/10.1007/s13353-016-0388-8. |
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@article{1381321,
author = {Pávková Goldbergová, Monika and Jarkovský, Jiří and Lipková, Jolana and Littnerová, Simona and Poloczek, Martin and Špinar, Jindřich and Kubková, Lenka and Kluz, Krystyna and Kala, Petr and Maňoušek, Jan and Vašků, Anna and Pařenica, Jiří},
article_location = {Heidelberg},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s13353-016-0388-8},
keywords = {MMP; Polymorphism; Prognosis; STEMI; TIMP},
language = {eng},
issn = {1234-1983},
journal = {Journal of Applied Genetics},
title = {Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction},
url = {http://dx.doi.org/10.1007/s13353-016-0388-8},
volume = {58},
year = {2017}
}
TY - JOUR
ID - 1381321
AU - Pávková Goldbergová, Monika - Jarkovský, Jiří - Lipková, Jolana - Littnerová, Simona - Poloczek, Martin - Špinar, Jindřich - Kubková, Lenka - Kluz, Krystyna - Kala, Petr - Maňoušek, Jan - Vašků, Anna - Pařenica, Jiří
PY - 2017
TI - Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction
JF - Journal of Applied Genetics
VL - 58
IS - 3
SP - 331-341
EP - 331-341
PB - Springer
SN - 12341983
KW - MMP
KW - Polymorphism
KW - Prognosis
KW - STEMI
KW - TIMP
UR - http://dx.doi.org/10.1007/s13353-016-0388-8
L2 - http://dx.doi.org/10.1007/s13353-016-0388-8
N2 - The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1.75 (p < 0.001); the variants with at least one A allele of MMP-1 -519A/G have less risk of combined endpoint. The TT variants of -1562C/T MMP-9 and at least one T allele of +92C/T MMP-13 were considered in a trend to affect disease progression and long-term survival after myocardial infarction. According to reclassification analysis NRI and IDI, long-term risk stratification using MMP-1 -422A/T and -519A/G polymorphisms gives additional information to the commonly used GRACE risk score. Patient stratification after myocardial infraction (MI) according to risk genotypes of MMP-1 polymorphisms could have important clinical implications for identification of patients at risk and therapeutic strategies.
ER -
PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří JARKOVSKÝ, Jolana LIPKOVÁ, Simona LITTNEROVÁ, Martin POLOCZEK, Jindřich ŠPINAR, Lenka KUBKOVÁ, Krystyna KLUZ, Petr KALA, Jan MAŇOUŠEK, Anna VAŠKŮ and Jiří PAŘENICA. Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction. \textit{Journal of Applied Genetics}. Heidelberg: Springer, 2017, vol.~58, No~3, p.~331-341. ISSN~1234-1983. Available from: https://dx.doi.org/10.1007/s13353-016-0388-8.
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