Relationship of long-term prognosis to MMP and TIMP
polymorphisms in patients after ST elevation myocardial
infarction

J 2017

Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří JARKOVSKÝ, Jolana LIPKOVÁ, Simona LITTNEROVÁ, Martin POLOCZEK et. al.

Basic information

Original name

Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction

Authors

PÁVKOVÁ GOLDBERGOVÁ, Monika (203 Czech Republic, guarantor, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution), Simona LITTNEROVÁ (203 Czech Republic, belonging to the institution), Martin POLOCZEK (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Lenka KUBKOVÁ (203 Czech Republic, belonging to the institution), Krystyna KLUZ (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution), Jan MAŇOUŠEK (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Jiří PAŘENICA (203 Czech Republic, belonging to the institution)

Edition

Journal of Applied Genetics, Heidelberg, Springer, 2017, 1234-1983

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30400 3.4 Medical biotechnology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.756

RIV identification code

RIV/00216224:14110/17:00096767

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s13353-016-0388-8

UT WoS

000405693600005

Keywords in English

MMP; Polymorphism; Prognosis; STEMI; TIMP

Abstract

V originále

The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1.75 (p < 0.001); the variants with at least one A allele of MMP-1 -519A/G have less risk of combined endpoint. The TT variants of -1562C/T MMP-9 and at least one T allele of +92C/T MMP-13 were considered in a trend to affect disease progression and long-term survival after myocardial infarction. According to reclassification analysis NRI and IDI, long-term risk stratification using MMP-1 -422A/T and -519A/G polymorphisms gives additional information to the commonly used GRACE risk score. Patient stratification after myocardial infraction (MI) according to risk genotypes of MMP-1 polymorphisms could have important clinical implications for identification of patients at risk and therapeutic strategies.

Links

LM2015090, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří JARKOVSKÝ, Jolana LIPKOVÁ, Simona LITTNEROVÁ, Martin POLOCZEK, Jindřich ŠPINAR, Lenka KUBKOVÁ, Krystyna KLUZ, Petr KALA, Jan MAŇOUŠEK, Anna VAŠKŮ and Jiří PAŘENICA. Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction. Journal of Applied Genetics. Heidelberg: Springer, 2017, vol. 58, No 3, p. 331-341. ISSN 1234-1983. Available from: https://dx.doi.org/10.1007/s13353-016-0388-8.

@article{1381321,
   author = {Pávková Goldbergová, Monika and Jarkovský, Jiří and Lipková, Jolana and Littnerová, Simona and Poloczek, Martin and Špinar, Jindřich and Kubková, Lenka and Kluz, Krystyna and Kala, Petr and Maňoušek, Jan and Vašků, Anna and Pařenica, Jiří},
   article_location = {Heidelberg},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s13353-016-0388-8},
   keywords = {MMP; Polymorphism; Prognosis; STEMI; TIMP},
   language = {eng},
   issn = {1234-1983},
   journal = {Journal of Applied Genetics},
   title = {Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction},
   url = {http://dx.doi.org/10.1007/s13353-016-0388-8},
   volume = {58},
   year = {2017}
}

TY  - JOUR
ID  - 1381321
AU  - Pávková Goldbergová, Monika - Jarkovský, Jiří - Lipková, Jolana - Littnerová, Simona - Poloczek, Martin - Špinar, Jindřich - Kubková, Lenka - Kluz, Krystyna - Kala, Petr - Maňoušek, Jan - Vašků, Anna - Pařenica, Jiří
PY  - 2017
TI  - Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction
JF  - Journal of Applied Genetics
VL  - 58
IS  - 3
SP  - 331-341
EP  - 331-341
PB  - Springer
SN  - 12341983
KW  - MMP
KW  - Polymorphism
KW  - Prognosis
KW  - STEMI
KW  - TIMP
UR  - http://dx.doi.org/10.1007/s13353-016-0388-8
L2  - http://dx.doi.org/10.1007/s13353-016-0388-8
N2  - The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1.75 (p < 0.001); the variants with at least one A allele of MMP-1 -519A/G have less risk of combined endpoint. The TT variants of -1562C/T MMP-9 and at least one T allele of +92C/T MMP-13 were considered in a trend to affect disease progression and long-term survival after myocardial infarction. According to reclassification analysis NRI and IDI, long-term risk stratification using MMP-1 -422A/T and -519A/G polymorphisms gives additional information to the commonly used GRACE risk score. Patient stratification after myocardial infraction (MI) according to risk genotypes of MMP-1 polymorphisms could have important clinical implications for identification of patients at risk and therapeutic strategies.
ER  -

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří JARKOVSKÝ, Jolana LIPKOVÁ, Simona LITTNEROVÁ, Martin POLOCZEK, Jindřich ŠPINAR, Lenka KUBKOVÁ, Krystyna KLUZ, Petr KALA, Jan MAŇOUŠEK, Anna VAŠKŮ and Jiří PAŘENICA. Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction. \textit{Journal of Applied Genetics}. Heidelberg: Springer, 2017, vol.~58, No~3, p.~331-341. ISSN~1234-1983. Available from: https://dx.doi.org/10.1007/s13353-016-0388-8.

Detailed Information on Publication Record