| KHAIRNAR, Amit Suresh, Jana RUDÁ, Nikoletta SZABÓ, Eva DRAŽANOVÁ, Anas ARAB, Birgit HUTTER-PAIER, Joerg NEDDENS, Peter LATTA, Zenon STARČUK and Irena REKTOROVÁ. Early and progressive microstructural brain changes in mice overexpressing human alpha-Synuclein detected by diffusion kurtosis imaging. Brain, Behavior, and Immunity. San Diego: Academic Press, 2017, vol. 61, March, p. 197-208. ISSN 0889-1591. Available from: https://dx.doi.org/10.1016/j.bbi.2016.11.027. |
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@article{1381942,
author = {Khairnar, Amit Suresh and Rudá, Jana and Szabó, Nikoletta and Dražanová, Eva and Arab, Anas and HutterandPaier, Birgit and Neddens, Joerg and Latta, Peter and Starčuk, Zenon and Rektorová, Irena},
article_location = {San Diego},
article_number = {March},
doi = {http://dx.doi.org/10.1016/j.bbi.2016.11.027},
keywords = {MRI; Diffusion kurtosis imaging; Substantia nigra; Striatum; Thalamus; TNWT-61; Parkinson's disease; Transgenic mice; Animal model},
language = {eng},
issn = {0889-1591},
journal = {Brain, Behavior, and Immunity},
title = {Early and progressive microstructural brain changes in mice overexpressing human alpha-Synuclein detected by diffusion kurtosis imaging},
url = {http://www.sciencedirect.com/science/article/pii/S0889159116305293},
volume = {61},
year = {2017}
}
TY - JOUR
ID - 1381942
AU - Khairnar, Amit Suresh - Rudá, Jana - Szabó, Nikoletta - Dražanová, Eva - Arab, Anas - Hutter-Paier, Birgit - Neddens, Joerg - Latta, Peter - Starčuk, Zenon - Rektorová, Irena
PY - 2017
TI - Early and progressive microstructural brain changes in mice overexpressing human alpha-Synuclein detected by diffusion kurtosis imaging
JF - Brain, Behavior, and Immunity
VL - 61
IS - March
SP - 197-208
EP - 197-208
PB - Academic Press
SN - 08891591
KW - MRI
KW - Diffusion kurtosis imaging
KW - Substantia nigra
KW - Striatum
KW - Thalamus
KW - TNWT-61
KW - Parkinson's disease
KW - Transgenic mice
KW - Animal model
UR - http://www.sciencedirect.com/science/article/pii/S0889159116305293
L2 - http://www.sciencedirect.com/science/article/pii/S0889159116305293
N2 - Diffusion kurtosis imaging (DKI) is sensitive in detecting alpha-Synuclein (alpha-Syn) accumulation-associated microstructural changes at late stages of the pathology in alpha-Syn overexpressing TNWT-61 mice. The aim of this study was to perform DKI in young TNWT-61 mice when alpha-Syn starts to accumulate and to compare the imaging results with an analysis of motor and memory impairment and alpha-Syn levels. Three-month-old (3mo) and six-month-old (6mo) mice underwent DIU scanning using the Bruker Avance 9.4 T magnetic resonance imaging system. Region of interest (ROI) analyses were performed in the gray matter; tract-based spatial statistics (TBSS) analyses were performed in the white matter. In the same mice, alpha-Syn expression was evaluated using quantitative immunofluorescence. Mean kurtosis (MK) was the best differentiator between TNWT-61 mice and wildtype (WT) mice. We found increases in MK in 3mo TNWT-61 mice in the striatum and thalamus but not in the substantia nigra (SN), hippocampus, or sensorimotor cortex, even though the immunoreactivity of human alpha-Syn was similar or even higher in the latter regions. Increases in MK in the SN were detected in 6mo mice. These findings indicate that alpha-Syn accumulation-associated changes may start in areas with a high density of dopaminergic nerve terminals. We also found TBSS changes in white matter only at 6mo, suggesting alpha-Syn accumulation-associated changes start in the gray matter and later progress to the white matter. MK is able to detect microstructural changes induced by alpha-Syn overexpression in TNWT-61 mice and could be a useful clinical tool for detecting early-stage Parkinson's disease in human patients. (C) 2016 Elsevier Inc. All rights reserved.
ER -
KHAIRNAR, Amit Suresh, Jana RUDÁ, Nikoletta SZABÓ, Eva DRAŽANOVÁ, Anas ARAB, Birgit HUTTER-PAIER, Joerg NEDDENS, Peter LATTA, Zenon STARČUK and Irena REKTOROVÁ. Early and progressive microstructural brain changes in mice overexpressing human alpha-Synuclein detected by diffusion kurtosis imaging. \textit{Brain, Behavior, and Immunity}. San Diego: Academic Press, 2017, vol.~61, March, p.~197-208. ISSN~0889-1591. Available from: https://dx.doi.org/10.1016/j.bbi.2016.11.027.
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