| AHMAD, Parwez, Jiří ŠÁNA, Marek SLAVIK, Pavel SLAMPA, Pavel SMILEK a Ondřej SLABÝ. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. Online. Disease Markers. London: Hindawi Publishing Corporation, 2017, roč. 2017, neuvedeno, s. nestránkováno, 8 s. ISSN 0278-0240. Dostupné z: https://dx.doi.org/10.1155/2017/8245345. [citováno 2024-04-24] |
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@article{1382001,
author = {Ahmad, Parwez and Šána, Jiří and Slavik, Marek and Slampa, Pavel and Smilek, Pavel and Slabý, Ondřej},
article_location = {London},
article_number = {neuvedeno},
doi = {http://dx.doi.org/10.1155/2017/8245345},
keywords = {SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN NASOPHARYNGEAL CARCINOMA; INCREASES RADIOSENSITIVITY; ENHANCES RADIOSENSITIVITY; IONIZING-RADIATION; GLIOBLASTOMA CELLS; ESOPHAGEAL CANCER; LUNG-CANCER; STEM-CELLS},
language = {eng},
issn = {0278-0240},
journal = {Disease Markers},
title = {MicroRNAs Involvement in Radioresistance of Head and Neck Cancer},
url = {https://www.hindawi.com/journals/dm/2017/8245345/},
volume = {2017},
year = {2017}
}
TY - JOUR
ID - 1382001
AU - Ahmad, Parwez - Šána, Jiří - Slavik, Marek - Slampa, Pavel - Smilek, Pavel - Slabý, Ondřej
PY - 2017
TI - MicroRNAs Involvement in Radioresistance of Head and Neck Cancer
JF - Disease Markers
VL - 2017
IS - neuvedeno
SP - nestránkováno
EP - nestránkováno
PB - Hindawi Publishing Corporation
SN - 02780240
KW - SQUAMOUS-CELL CARCINOMA
KW - EPITHELIAL-MESENCHYMAL TRANSITION
KW - HUMAN NASOPHARYNGEAL CARCINOMA
KW - INCREASES RADIOSENSITIVITY
KW - ENHANCES RADIOSENSITIVITY
KW - IONIZING-RADIATION
KW - GLIOBLASTOMA CELLS
KW - ESOPHAGEAL CANCER
KW - LUNG-CANCER
KW - STEM-CELLS
UR - https://www.hindawi.com/journals/dm/2017/8245345/
L2 - https://www.hindawi.com/journals/dm/2017/8245345/
N2 - Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs. MicroRNAs are short endogenous RNA molecules that posttranscriptionally modulate gene expression and their deregulated expression has been observed in many tumors including head and neck cancer. Specific expression patterns of microRNAs have also been shown to predict prognosis and therapeutic response in head and neck cancer. Therefore, microRNAs present promising biomarkers and therapeutic targets that might overcome resistance to radiation and improve prognosis of head and neck cancer patients. In this review, we summarize the current knowledge of the functional role of microRNAs in radioresistance of cancer with special focus on head and neck cancer.
ER -
AHMAD, Parwez, Jiří ŠÁNA, Marek SLAVIK, Pavel SLAMPA, Pavel SMILEK a Ondřej SLABÝ. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. Online. \textit{Disease Markers}. London: Hindawi Publishing Corporation, 2017, roč.~2017, neuvedeno, s.~nestránkováno, 8 s. ISSN~0278-0240. Dostupné z: https://dx.doi.org/10.1155/2017/8245345. [citováno 2024-04-24]
|
