AHMAD, Parwez, Jiří ŠÁNA, Marek SLAVIK, Pavel SLAMPA, Pavel SMILEK and Ondřej SLABÝ. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. Disease Markers. London: Hindawi Publishing Corporation, 2017, vol. 2017, neuvedeno, p. nestránkováno, 8 pp. ISSN 0278-0240. Available from: https://dx.doi.org/10.1155/2017/8245345. |
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@article{1382001, author = {Ahmad, Parwez and Šána, Jiří and Slavik, Marek and Slampa, Pavel and Smilek, Pavel and Slabý, Ondřej}, article_location = {London}, article_number = {neuvedeno}, doi = {http://dx.doi.org/10.1155/2017/8245345}, keywords = {SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN NASOPHARYNGEAL CARCINOMA; INCREASES RADIOSENSITIVITY; ENHANCES RADIOSENSITIVITY; IONIZING-RADIATION; GLIOBLASTOMA CELLS; ESOPHAGEAL CANCER; LUNG-CANCER; STEM-CELLS}, language = {eng}, issn = {0278-0240}, journal = {Disease Markers}, title = {MicroRNAs Involvement in Radioresistance of Head and Neck Cancer}, url = {https://www.hindawi.com/journals/dm/2017/8245345/}, volume = {2017}, year = {2017} }
TY - JOUR ID - 1382001 AU - Ahmad, Parwez - Šána, Jiří - Slavik, Marek - Slampa, Pavel - Smilek, Pavel - Slabý, Ondřej PY - 2017 TI - MicroRNAs Involvement in Radioresistance of Head and Neck Cancer JF - Disease Markers VL - 2017 IS - neuvedeno SP - nestránkováno EP - nestránkováno PB - Hindawi Publishing Corporation SN - 02780240 KW - SQUAMOUS-CELL CARCINOMA KW - EPITHELIAL-MESENCHYMAL TRANSITION KW - HUMAN NASOPHARYNGEAL CARCINOMA KW - INCREASES RADIOSENSITIVITY KW - ENHANCES RADIOSENSITIVITY KW - IONIZING-RADIATION KW - GLIOBLASTOMA CELLS KW - ESOPHAGEAL CANCER KW - LUNG-CANCER KW - STEM-CELLS UR - https://www.hindawi.com/journals/dm/2017/8245345/ L2 - https://www.hindawi.com/journals/dm/2017/8245345/ N2 - Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs. MicroRNAs are short endogenous RNA molecules that posttranscriptionally modulate gene expression and their deregulated expression has been observed in many tumors including head and neck cancer. Specific expression patterns of microRNAs have also been shown to predict prognosis and therapeutic response in head and neck cancer. Therefore, microRNAs present promising biomarkers and therapeutic targets that might overcome resistance to radiation and improve prognosis of head and neck cancer patients. In this review, we summarize the current knowledge of the functional role of microRNAs in radioresistance of cancer with special focus on head and neck cancer. ER -
AHMAD, Parwez, Jiří ŠÁNA, Marek SLAVIK, Pavel SLAMPA, Pavel SMILEK and Ondřej SLABÝ. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. \textit{Disease Markers}. London: Hindawi Publishing Corporation, 2017, vol.~2017, neuvedeno, p.~nestránkováno, 8 pp. ISSN~0278-0240. Available from: https://dx.doi.org/10.1155/2017/8245345.
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