SLC22A3 polymorphisms do not modify pancreatic cancer risk, but
may influence overall patient survival

J 2017

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

MOHELNIKOVA-DUCHONOVA, Beatrice, Ondrej STROUHAL, David J. HUGHES, Ivana HOLCATOVA, Martin OLIVERIUS et. al.

Basic information

Original name

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

Authors

MOHELNIKOVA-DUCHONOVA, Beatrice (203 Czech Republic), Ondrej STROUHAL (203 Czech Republic), David J. HUGHES (372 Ireland), Ivana HOLCATOVA (203 Czech Republic), Martin OLIVERIUS (203 Czech Republic), Zdeněk KALA (203 Czech Republic, guarantor, belonging to the institution), Daniele CAMPA (276 Germany), Cosmeri RIZZATO (276 Germany), Federico CANZIAN (276 Germany), Raffaele PEZZILLI (380 Italy), Renata TALAR-WOJNAROWSKA (616 Poland), Ewa MALECKA-PANAS (616 Poland), Cosimo SPERTI (380 Italy), Carlo Federico ZAMBON (380 Italy), Serdio PEDRAZZOLI (380 Italy), Paola FOGAR (380 Italy), Anna Caterina MILANETTO (380 Italy), Gabriele CAPURSO (380 Italy), Giafranco Delle FAVE (380 Italy), Roberto VALENTE (380 Italy), Maria GAZOULI (300 Greece), Giuseppe MALLEO (380 Italy), Rita Teresa LAWLOR (380 Italy), Oliver STROBEL (276 Germany), Thilo HACKERT (276 Germany), Nathalia GIESE (276 Germany), Pavel VODICKA (203 Czech Republic), Ludmila VODICKOVA (203 Czech Republic), Stefano LANDI (380 Italy), Francesca TAVANO (380 Italy), Domenica GIOFFREDA (380 Italy), Ada PIEPOLI (380 Italy), Valerio PAZIENZA (380 Italy), Andrea MAMBRINI (380 Italy), Mariangela PEDATA (380 Italy), Maurizio CANTORE (380 Italy), Franco BAMBI (380 Italy), Stefano ERMINI (380 Italy), Niccola FUNEL (380 Italy), Radmila LEMSTROVA (203 Czech Republic) and Pavel SOUCEK (203 Czech Republic)

Edition

Scientific Reports, London, Nature Publishing Group, 2017, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.122

RIV identification code

RIV/00216224:14110/17:00096878

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/srep43812

UT WoS

000395686300001

Keywords in English

pancreatic cancer

Abstract

V originále

Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability in SLC22A3 associates with pancreatic cancer risk and prognosis. Twenty four single nucleotide polymorphisms (SNPs) tagging the SLC22A3 gene sequence and regulatory elements were selected for analysis. Of these, 22 were successfully evaluated in the discovery phase while six significant or suggestive variants entered the validation phase, comprising a total study number of 1,518 cases and 3,908 controls. In the discovery phase, rs2504938, rs9364554, and rs2457571 SNPs were significantly associated with pancreatic cancer risk.

Citovat

MOHELNIKOVA-DUCHONOVA, Beatrice, Ondrej STROUHAL, David J. HUGHES, Ivana HOLCATOVA, Martin OLIVERIUS, Zdeněk KALA, Daniele CAMPA, Cosmeri RIZZATO, Federico CANZIAN, Raffaele PEZZILLI, Renata TALAR-WOJNAROWSKA, Ewa MALECKA-PANAS, Cosimo SPERTI, Carlo Federico ZAMBON, Serdio PEDRAZZOLI, Paola FOGAR, Anna Caterina MILANETTO, Gabriele CAPURSO, Giafranco Delle FAVE, Roberto VALENTE, Maria GAZOULI, Giuseppe MALLEO, Rita Teresa LAWLOR, Oliver STROBEL, Thilo HACKERT, Nathalia GIESE, Pavel VODICKA, Ludmila VODICKOVA, Stefano LANDI, Francesca TAVANO, Domenica GIOFFREDA, Ada PIEPOLI, Valerio PAZIENZA, Andrea MAMBRINI, Mariangela PEDATA, Maurizio CANTORE, Franco BAMBI, Stefano ERMINI, Niccola FUNEL, Radmila LEMSTROVA and Pavel SOUCEK. SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival. Scientific Reports. London: Nature Publishing Group, 2017, vol. 7, No 43812, p. 1-11. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/srep43812.

@article{1382082,
   author = {MohelnikovaandDuchonova, Beatrice and Strouhal, Ondrej and Hughes, David J. and Holcatova, Ivana and Oliverius, Martin and Kala, Zdeněk and Campa, Daniele and Rizzato, Cosmeri and Canzian, Federico and Pezzilli, Raffaele and TalarandWojnarowska, Renata and MaleckaandPanas, Ewa and Sperti, Cosimo and Zambon, Carlo Federico and Pedrazzoli, Serdio and Fogar, Paola and Milanetto, Anna Caterina and Capurso, Gabriele and Fave, Giafranco Delle and Valente, Roberto and Gazouli, Maria and Malleo, Giuseppe and Lawlor, Rita Teresa and Strobel, Oliver and Hackert, Thilo and Giese, Nathalia and Vodicka, Pavel and Vodickova, Ludmila and Landi, Stefano and Tavano, Francesca and Gioffreda, Domenica and Piepoli, Ada and Pazienza, Valerio and Mambrini, Andrea and Pedata, Mariangela and Cantore, Maurizio and Bambi, Franco and Ermini, Stefano and Funel, Niccola and Lemstrova, Radmila and Soucek, Pavel},
   article_location = {London},
   article_number = {43812},
   doi = {http://dx.doi.org/10.1038/srep43812},
   keywords = {pancreatic cancer},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival},
   volume = {7},
   year = {2017}
}

TY  - JOUR
ID  - 1382082
AU  - Mohelnikova-Duchonova, Beatrice - Strouhal, Ondrej - Hughes, David J. - Holcatova, Ivana - Oliverius, Martin - Kala, Zdeněk - Campa, Daniele - Rizzato, Cosmeri - Canzian, Federico - Pezzilli, Raffaele - Talar-Wojnarowska, Renata - Malecka-Panas, Ewa - Sperti, Cosimo - Zambon, Carlo Federico - Pedrazzoli, Serdio - Fogar, Paola - Milanetto, Anna Caterina - Capurso, Gabriele - Fave, Giafranco Delle - Valente, Roberto - Gazouli, Maria - Malleo, Giuseppe - Lawlor, Rita Teresa - Strobel, Oliver - Hackert, Thilo - Giese, Nathalia - Vodicka, Pavel - Vodickova, Ludmila - Landi, Stefano - Tavano, Francesca - Gioffreda, Domenica - Piepoli, Ada - Pazienza, Valerio - Mambrini, Andrea - Pedata, Mariangela - Cantore, Maurizio - Bambi, Franco - Ermini, Stefano - Funel, Niccola - Lemstrova, Radmila - Soucek, Pavel
PY  - 2017
TI  - SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival
JF  - Scientific Reports
VL  - 7
IS  - 43812
SP  - 1-11
EP  - 1-11
PB  - Nature Publishing Group
SN  - 20452322
KW  - pancreatic cancer
N2  - Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability in SLC22A3 associates with pancreatic cancer risk and prognosis. Twenty four single nucleotide polymorphisms (SNPs) tagging the SLC22A3 gene sequence and regulatory elements were selected for analysis. Of these, 22 were successfully evaluated in the discovery phase while six significant or suggestive variants entered the validation phase, comprising a total study number of 1,518 cases and 3,908 controls. In the discovery phase, rs2504938, rs9364554, and rs2457571 SNPs were significantly associated with pancreatic cancer risk.
ER  -

MOHELNIKOVA-DUCHONOVA, Beatrice, Ondrej STROUHAL, David J. HUGHES, Ivana HOLCATOVA, Martin OLIVERIUS, Zdeněk KALA, Daniele CAMPA, Cosmeri RIZZATO, Federico CANZIAN, Raffaele PEZZILLI, Renata TALAR-WOJNAROWSKA, Ewa MALECKA-PANAS, Cosimo SPERTI, Carlo Federico ZAMBON, Serdio PEDRAZZOLI, Paola FOGAR, Anna Caterina MILANETTO, Gabriele CAPURSO, Giafranco Delle FAVE, Roberto VALENTE, Maria GAZOULI, Giuseppe MALLEO, Rita Teresa LAWLOR, Oliver STROBEL, Thilo HACKERT, Nathalia GIESE, Pavel VODICKA, Ludmila VODICKOVA, Stefano LANDI, Francesca TAVANO, Domenica GIOFFREDA, Ada PIEPOLI, Valerio PAZIENZA, Andrea MAMBRINI, Mariangela PEDATA, Maurizio CANTORE, Franco BAMBI, Stefano ERMINI, Niccola FUNEL, Radmila LEMSTROVA and Pavel SOUCEK. SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival. \textit{Scientific Reports}. London: Nature Publishing Group, 2017, vol.~7, No~43812, p.~1-11. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/srep43812.

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