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@article{1382666,
author = {Bartáková, Vendula and Chalásová, Katarína and Zlámal, Filip and Bělobrádková, Jana and Kaňková, Kateřina},
article_location = {Heidelberg},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s00394-016-1334-6},
keywords = {Dietary intake; Food preferences; Genetic variability; Gestational diabetes mellitus; Single nucleotide polymorphism; Taste receptors},
language = {eng},
issn = {1436-6207},
journal = {European Journal of Nutrition},
title = {Differences in food intake and genetic variability in taste receptors between Czech pregnant women with and without gestational diabetes mellitus},
volume = {57},
year = {2018}
}
TY - JOUR
ID - 1382666
AU - Bartáková, Vendula - Chalásová, Katarína - Zlámal, Filip - Bělobrádková, Jana - Kaňková, Kateřina
PY - 2018
TI - Differences in food intake and genetic variability in taste receptors between Czech pregnant women with and without gestational diabetes mellitus
JF - European Journal of Nutrition
VL - 57
IS - 2
SP - 513-521
EP - 513-521
PB - Springer
SN - 14366207
KW - Dietary intake
KW - Food preferences
KW - Genetic variability
KW - Gestational diabetes mellitus
KW - Single nucleotide polymorphism
KW - Taste receptors
N2 - Purpose: Gestational diabetes mellitus (GDM) represents the most frequent metabolic disorder in pregnancy. Since dietary intake plays an important role in obesity and type 2 diabetes development, it is likely to be for the susceptibility to GDM too. Food preferences, driving partly the diet composition, are changing during pregnancy. Taste and genetic variability in taste receptors is an important factor in determining food preferences. Aims of our study were (1) to characterize dietary habits of pregnant women and to find possible differences in food preferences between healthy pregnant women and those with GDM and (2) to ascertain possible association of several single nucleotide polymorphisms (SNPs) in taste receptor (TR) genes with GDM. Methods: A total of 363 pregnant women (293 with GDM and 70 with physiologic pregnancy) were included in the study. Dietary pattern spanning the period of approx. 6 months preceding the time of GDM screening was assessed using a semi-quantitative food frequency questionnaire. A total of five SNPs in TR genes were selected for genotyping based on their functionality or previous associations. Results: Women with GDM exhibited significantly more frequent meat consumption (esp. poultry, pork and smoked meat), dairy products and sweet beverages consumption. The legumes consumption was found to be inversely correlated with fasting glycaemia (P = 0.007, Spearman). CC genotype in TAS2R9 gene (SNP rs3741845) was significantly associated with GDM (P = 0.0087, Chi-square test). Conclusions: Our study showed differences in dietary intake of selected food items between healthy pregnant women and those with GDM and genetic association of bitter taste receptor allele with GDM.
ER -
BARTÁKOVÁ, Vendula, Katarína CHALÁSOVÁ, Filip ZLÁMAL, Jana BĚLOBRÁDKOVÁ and Kateřina KAŇKOVÁ. Differences in food intake and genetic variability in taste receptors between Czech pregnant women with and without gestational diabetes mellitus. \textit{European Journal of Nutrition}. Heidelberg: Springer, 2018, vol.~57, No~2, p.~513-521. ISSN~1436-6207. Available from: https://dx.doi.org/10.1007/s00394-016-1334-6.
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