Phenotypes of COPD patients with a smoking history in Central
and Eastern Europe: the POPE Study

J 2017

Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study

KOBLIZEK, Vladimir, Branislava MILENKOVIC, Adam BARCZYK, Ruzena TKACOVA, Attila SOMFAY et. al.

Basic information

Original name

Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study

Authors

KOBLIZEK, Vladimir (203 Czech Republic), Branislava MILENKOVIC (688 Serbia), Adam BARCZYK (616 Poland), Ruzena TKACOVA (703 Slovakia), Attila SOMFAY (348 Hungary), Kirill ZYKOV (643 Russian Federation), Neven TUDORIC (191 Croatia), Kosta KOSTOV (100 Bulgaria), Zuzana ZBOŽÍNKOVÁ (203 Czech Republic, guarantor, belonging to the institution), Jan ŠVANCARA (203 Czech Republic, belonging to the institution), Jurij SORLI (705 Slovenia), Alvils KRAMS (440 Lithuania), Marc MIRAVITLLES (724 Spain) and Arschang VALIPOUR (40 Austria)

Edition

European Respiratory Journal, Sheffield, European Respiratory Society Journals Ltd. 2017, 0903-1936

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30203 Respiratory systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 12.244

RIV identification code

RIV/00216224:14110/17:00096971

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1183/13993003.01446-2016

UT WoS

000401788800005

Keywords in English

Chronic obstructive pulmonary disease

Abstract

V originále

Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries; however, there are no data regarding clinical phenotypes of these patients in this region. Participation in the Phenotypes of COPD in Central and Eastern Europe (POPE) study was offered to stable patients with COPD in a real-life setting. The primary aim of this study was to assess the prevalence of phenotypes according to predefined criteria. Secondary aims included analysis of differences in symptom load, comorbidities and pharmacological treatment. 3362 patients with COPD were recruited in 10 CEE countries. 63% of the population were nonexacerbators, 20.4% frequent exacerbators with chronic bronchitis, 9.5% frequent exacerbators without chronic bronchitis and 6.9% were classified as asthma-COPD overlap. Differences in the distribution of phenotypes between countries were observed, with the highest heterogeneity observed in the nonexacerbator cohort and the lowest heterogeneity observed in the asthma-COPD cohort. There were statistically significant differences in symptom load, lung function, comorbidities and treatment between these phenotypes. The majority of patients with stable COPD in CEE are nonexacerbators; however, there are distinct differences in surrogates of disease severity and therapy between predefined COPD phenotypes.

Citovat

KOBLIZEK, Vladimir, Branislava MILENKOVIC, Adam BARCZYK, Ruzena TKACOVA, Attila SOMFAY, Kirill ZYKOV, Neven TUDORIC, Kosta KOSTOV, Zuzana ZBOŽÍNKOVÁ, Jan ŠVANCARA, Jurij SORLI, Alvils KRAMS, Marc MIRAVITLLES and Arschang VALIPOUR. Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study. European Respiratory Journal. Sheffield: European Respiratory Society Journals Ltd., 2017, vol. 49, No 5, p. 1-10. ISSN 0903-1936. Available from: https://dx.doi.org/10.1183/13993003.01446-2016.

@article{1383148,
   author = {Koblizek, Vladimir and Milenkovic, Branislava and Barczyk, Adam and Tkacova, Ruzena and Somfay, Attila and Zykov, Kirill and Tudoric, Neven and Kostov, Kosta and Zbožínková, Zuzana and Švancara, Jan and Sorli, Jurij and Krams, Alvils and Miravitlles, Marc and Valipour, Arschang},
   article_location = {Sheffield},
   article_number = {5},
   doi = {http://dx.doi.org/10.1183/13993003.01446-2016},
   keywords = {Chronic obstructive pulmonary disease},
   language = {eng},
   issn = {0903-1936},
   journal = {European Respiratory Journal},
   title = {Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study},
   volume = {49},
   year = {2017}
}

TY  - JOUR
ID  - 1383148
AU  - Koblizek, Vladimir - Milenkovic, Branislava - Barczyk, Adam - Tkacova, Ruzena - Somfay, Attila - Zykov, Kirill - Tudoric, Neven - Kostov, Kosta - Zbožínková, Zuzana - Švancara, Jan - Sorli, Jurij - Krams, Alvils - Miravitlles, Marc - Valipour, Arschang
PY  - 2017
TI  - Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study
JF  - European Respiratory Journal
VL  - 49
IS  - 5
SP  - 1-10
EP  - 1-10
PB  - European Respiratory Society Journals Ltd.
SN  - 09031936
KW  - Chronic obstructive pulmonary disease
N2  - Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries; however, there are no data regarding clinical phenotypes of these patients in this region. Participation in the Phenotypes of COPD in Central and Eastern Europe (POPE) study was offered to stable patients with COPD in a real-life setting. The primary aim of this study was to assess the prevalence of phenotypes according to predefined criteria. Secondary aims included analysis of differences in symptom load, comorbidities and pharmacological treatment. 3362 patients with COPD were recruited in 10 CEE countries. 63% of the population were nonexacerbators, 20.4% frequent exacerbators with chronic bronchitis, 9.5% frequent exacerbators without chronic bronchitis and 6.9% were classified as asthma-COPD overlap. Differences in the distribution of phenotypes between countries were observed, with the highest heterogeneity observed in the nonexacerbator cohort and the lowest heterogeneity observed in the asthma-COPD cohort. There were statistically significant differences in symptom load, lung function, comorbidities and treatment between these phenotypes. The majority of patients with stable COPD in CEE are nonexacerbators; however, there are distinct differences in surrogates of disease severity and therapy between predefined COPD phenotypes.
ER  -

KOBLIZEK, Vladimir, Branislava MILENKOVIC, Adam BARCZYK, Ruzena TKACOVA, Attila SOMFAY, Kirill ZYKOV, Neven TUDORIC, Kosta KOSTOV, Zuzana ZBOŽÍNKOVÁ, Jan ŠVANCARA, Jurij SORLI, Alvils KRAMS, Marc MIRAVITLLES and Arschang VALIPOUR. Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study. \textit{European Respiratory Journal}. Sheffield: European Respiratory Society Journals Ltd., 2017, vol.~49, No~5, p.~1-10. ISSN~0903-1936. Available from: https://dx.doi.org/10.1183/13993003.01446-2016.

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