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@article{1383183, author = {Gajarský, Martin and Zivkovic, Martina Lenarcic and Stadlbauer, Petr and Pagano, Bruno and Fiala, Radovan and Amato, Jussara and Tomaska, L´ubomir and Šponer, Jiří and Plavec, Janez and Trantírek, Lukáš}, article_location = {WASHINGTON}, article_number = {10}, doi = {http://dx.doi.org/10.1021/jacs.6b10786}, keywords = {G-QUADRUPLEX STRUCTURES; HUMAN TELOMERIC DNA; SINGLE-STRANDED-DNA; G-TRIPLEX; FOLDING PATHWAYS; KINETICS; RECOGNITION; VISUALIZATION; DETERMINANTS; REPEATS}, language = {eng}, issn = {0002-7863}, journal = {Journal of the American Chemical Society}, title = {Structure of a Stable G-Hairpin}, url = {http://pubs.acs.org/doi/abs/10.1021/jacs.6b10786}, volume = {139}, year = {2017} }
TY - JOUR ID - 1383183 AU - Gajarský, Martin - Zivkovic, Martina Lenarcic - Stadlbauer, Petr - Pagano, Bruno - Fiala, Radovan - Amato, Jussara - Tomaska, L´ubomir - Šponer, Jiří - Plavec, Janez - Trantírek, Lukáš PY - 2017 TI - Structure of a Stable G-Hairpin JF - Journal of the American Chemical Society VL - 139 IS - 10 SP - 3591-3594 EP - 3591-3594 PB - American Chemical Society SN - 00027863 KW - G-QUADRUPLEX STRUCTURES KW - HUMAN TELOMERIC DNA KW - SINGLE-STRANDED-DNA KW - G-TRIPLEX KW - FOLDING PATHWAYS KW - KINETICS KW - RECOGNITION KW - VISUALIZATION KW - DETERMINANTS KW - REPEATS UR - http://pubs.acs.org/doi/abs/10.1021/jacs.6b10786 L2 - http://pubs.acs.org/doi/abs/10.1021/jacs.6b10786 N2 - In this study, we report the first atomic resolution structure of a stable G-hairpin formed by a natively occurring DNA sequence. An 11-nt long G-rich DNA oligonucleotide, 5'-d(GTGTGGGTGTG)-3', corresponding to the most abundant sequence motif in irregular telomeric DNA from Saccharomyces cerevisiae (yeast), is demonstrated to adopt a novel type of mixed parallel/ antiparallel fold-back DNA structure, which is stabilized by dynamic G:G base pairs that transit between NI -carbonyl symmetric and N1-carbonyl, N7-aminobase-pairingarrangements. Although the studied sequence first appears to possess a low capacity for base pairing, it forms a thermodynamically stable structure with a rather complex topology that includes a chain reversal arrangement of the backbone in the center of the continuous G-tract and 3' to -5' stacking of the terminal residues. The structure reveals previously unknown principles of the folding of G rich oligonucleotides that could be applied to the prediction of natural and/or the design of artificial recognition DNA elements. The structure also demonstrates that the folding landscapes of short DNA single strands is much more complex than previously assumed. ER -
GAJARSKÝ, Martin, Martina Lenarcic ZIVKOVIC, Petr STADLBAUER, Bruno PAGANO, Radovan FIALA, Jussara AMATO, L´ubomir TOMASKA, Jiří ŠPONER, Janez PLAVEC and Lukáš TRANTÍREK. Structure of a Stable G-Hairpin. \textit{Journal of the American Chemical Society}. WASHINGTON: American Chemical Society, 2017, vol.~139, No~10, p.~3591-3594. ISSN~0002-7863. Available from: https://dx.doi.org/10.1021/jacs.6b10786.
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