Changes in BMI in hospitalized patients during treatment with
antipsychotics, depending on gender and other factors

J 2017

Changes in BMI in hospitalized patients during treatment with antipsychotics, depending on gender and other factors

SUŠILOVÁ, Lenka, Eva ČEŠKOVÁ, David HAMPEL, Aleš SUŠIL, Jan ŠIMŮNEK et. al.

Basic information

Original name

Changes in BMI in hospitalized patients during treatment with antipsychotics, depending on gender and other factors

Authors

SUŠILOVÁ, Lenka (203 Czech Republic, guarantor, belonging to the institution), Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution), David HAMPEL (203 Czech Republic), Aleš SUŠIL (203 Czech Republic) and Jan ŠIMŮNEK (203 Czech Republic, belonging to the institution)

Edition

International Journal of Psychiatry in Clinical Practice, ABINGDON, Informa Healthcare, 2017, 1365-1501

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30215 Psychiatry

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.337

RIV identification code

RIV/00216224:14110/17:00097041

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1080/13651501.2017.1291818

UT WoS

000401526900006

Keywords in English

Schizophrenia; body mass index; second generation antipsychotics; monotherapy; polytherapy

Abstract

V originále

Objective: To investigate the differences in body mass index (BMI) changes between men and women during hospitalization. Methods: The retrospective study monitored demographic and clinical data of 462 schizophrenic patients hospitalized 737 times between 2006 and 2011. BMI analysis was performed on patients on antipsychotic medication hospitalized longer than four days. Results: Patients with an initial BMI < 25 gained more weight than patients with a BMI > 25 (3.94% vs. 0.23%, men 4.02% vs. 0.69%, women 3.79% vs. -0.52%, always p < 0.001). Greater BMI gains were reported during the first hospitalization than during subsequent ones (3.94% vs. 1.66%, men 3.97% vs. 1.98%, women 3.88% vs. 1.18%, always p < 0.001). The comparison between men and women showed a higher increase in BMI in men 2.36% vs. 1.54%, p = 0.022. Men also gained significantly more weight than women on polytherapy (+2.55% vs. +1.37%) and during subsequent hospitalizations (1.98% vs. 1.18%). For treatment with various atypical antipsychotics (AP), no significant differences were found in weight changes between men and women; during treatment using a combination of multi-receptor AP and metabolically neutral aripiprazole, a significant increase of BMI occurred in men, but not in women (p = 0.018). Conclusions: Men appear to be more prone to weight gain than women.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

SUŠILOVÁ, Lenka, Eva ČEŠKOVÁ, David HAMPEL, Aleš SUŠIL and Jan ŠIMŮNEK. Changes in BMI in hospitalized patients during treatment with antipsychotics, depending on gender and other factors. International Journal of Psychiatry in Clinical Practice. ABINGDON: Informa Healthcare, 2017, vol. 21, No 2, p. 112-117. ISSN 1365-1501. Available from: https://dx.doi.org/10.1080/13651501.2017.1291818.

@article{1383726,
   author = {Sušilová, Lenka and Češková, Eva and Hampel, David and Sušil, Aleš and Šimůnek, Jan},
   article_location = {ABINGDON},
   article_number = {2},
   doi = {http://dx.doi.org/10.1080/13651501.2017.1291818},
   keywords = {Schizophrenia; body mass index; second generation antipsychotics; monotherapy; polytherapy},
   language = {eng},
   issn = {1365-1501},
   journal = {International Journal of Psychiatry in Clinical Practice},
   title = {Changes in BMI in hospitalized patients during treatment with antipsychotics, depending on gender and other factors},
   volume = {21},
   year = {2017}
}

TY  - JOUR
ID  - 1383726
AU  - Sušilová, Lenka - Češková, Eva - Hampel, David - Sušil, Aleš - Šimůnek, Jan
PY  - 2017
TI  - Changes in BMI in hospitalized patients during treatment with antipsychotics, depending on gender and other factors
JF  - International Journal of Psychiatry in Clinical Practice
VL  - 21
IS  - 2
SP  - 112-117
EP  - 112-117
PB  - Informa Healthcare
SN  - 13651501
KW  - Schizophrenia
KW  - body mass index
KW  - second generation antipsychotics
KW  - monotherapy
KW  - polytherapy
N2  - Objective: To investigate the differences in body mass index (BMI) changes between men and women during hospitalization. Methods: The retrospective study monitored demographic and clinical data of 462 schizophrenic patients hospitalized 737 times between 2006 and 2011. BMI analysis was performed on patients on antipsychotic medication hospitalized longer than four days. Results: Patients with an initial BMI < 25 gained more weight than patients with a BMI > 25 (3.94% vs. 0.23%, men 4.02% vs. 0.69%, women 3.79% vs. -0.52%, always p < 0.001). Greater BMI gains were reported during the first hospitalization than during subsequent ones (3.94% vs. 1.66%, men 3.97% vs. 1.98%, women 3.88% vs. 1.18%, always p < 0.001). The comparison between men and women showed a higher increase in BMI in men 2.36% vs. 1.54%, p = 0.022. Men also gained significantly more weight than women on polytherapy (+2.55% vs. +1.37%) and during subsequent hospitalizations (1.98% vs. 1.18%). For treatment with various atypical antipsychotics (AP), no significant differences were found in weight changes between men and women; during treatment using a combination of multi-receptor AP and metabolically neutral aripiprazole, a significant increase of BMI occurred in men, but not in women (p = 0.018). Conclusions: Men appear to be more prone to weight gain than women.
ER  -

SUŠILOVÁ, Lenka, Eva ČEŠKOVÁ, David HAMPEL, Aleš SUŠIL and Jan ŠIMŮNEK. Changes in BMI in hospitalized patients during treatment with antipsychotics, depending on gender and other factors. \textit{International Journal of Psychiatry in Clinical Practice}. ABINGDON: Informa Healthcare, 2017, vol.~21, No~2, p.~112-117. ISSN~1365-1501. Available from: https://dx.doi.org/10.1080/13651501.2017.1291818.

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