Detailed Information on Publication Record
2017
The NOD-like receptor (NLRP3) gene variability in patients with recurrent aphthous stomatitis
VALOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Lucie MASOPUSTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ et. al.Basic information
Original name
The NOD-like receptor (NLRP3) gene variability in patients with recurrent aphthous stomatitis
Authors
VALOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Lucie MASOPUSTOVÁ (203 Czech Republic, belonging to the institution), Jiřina BÁRTOVÁ (203 Czech Republic), Jitka PETANOVÁ (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
8th European Immunology Conference, Madrid, Spain, 2017
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30208 Dentistry, oral surgery and medicine
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/17:00100712
Organization unit
Faculty of Medicine
ISSN
Keywords in English
recurrent aphthous stomatitis; NLRP3; polymorphism
Změněno: 18/1/2019 13:26, Mgr. et Mgr. Simona Slezáková, Ph.D.
Abstract
V originále
Statement of the Problem: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with an unclear etiopathogenesis, resulting from the interplay between genetic and environmental factors. As the dysregulation of the immune system can play a role in the RAS development, single nucleotide polymorphisms (SNPs) in the genes for immune and inflammatory molecules were studied. The NOD-like receptor (NLRP3) gene, encoding the component of the inflammasome, has been proposed as one of the candidate genes for RAS. The aim of our study was to investigate three SNPs (rs4612666, rs10754558, rs3806265) in NLRP3 gene in patients with RAS and healthy controls in the Caucasian population Methodology: A total of 200 Czech subjects were enrolled in this case-control study. 143 healthy controls, 57 patients with RAS were genotyped by method based on polymerase chain reaction using 5´ nuclease TaqMan assays. Clinical parameters such as complete blood count, levels of immunoglobulins including allergen-specific immunoglobulin E or presence of antibodies against cytomegalovirus, Epstein-Barr virus were determined in RAS patients. Findings: Although no significant differences in the NLRP3 (rs10754558, rs3806265) allele and genotype frequencies between patients with RAS and controls were observed, statistically significant differences in NLRP3 rs4612666 genotype frequencies between subjects with RAS and controls were found. Carriers of NLRP3 rs4612666 TT genotype had a higher risk of developing RAS in comparison to subjects with CT + CC genotypes (OR = 16.71, 95% CI = 1.96-142.14, P = 0.0024). No association between NLRP3 haplotypes and RAS was detected. Conclusion; Significance: In contrast to the previous study5, associations between NLRP3 (rs10754558, rs3806265) polymorphisms and RAS were not confirmed. However, we suggest that NLRP3 rs4612666 polymorphism can strongly influence the risk of developing RAS in the Czech population.
Links
| GB14-37368G, research and development project |
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| MUNI/A/0948/2016, interní kód MU |
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| NV15-29336A, research and development project |
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