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@inproceedings{1385022,
author = {Botka, Tibor and Růžičková, Vladislava and Svobodová, Karla and Pantůček, Roman and Petráš, Petr and Čejková, Darina and Doškař, Jiří},
address = {Germany},
booktitle = {EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology},
editor = {Carolina Garcia Sabaté},
keywords = {ETB plasmid; exfoliative toxin B; phylogeny; genome analysis},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Germany},
note = {Nepřenášíme do RIV, výsledek má jen 1 stranu, podle metodiky M17+ musí mít stať ve sborníku min. 2 strany.},
pages = {122-122},
publisher = {EMBL Heidelberg, Germany},
title = {Characterization of two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus},
url = {https://www.embo-embl-symposia.org/symposia/2017/EES17-05/index.html},
year = {2017}
}
TY - JOUR
ID - 1385022
AU - Botka, Tibor - Růžičková, Vladislava - Svobodová, Karla - Pantůček, Roman - Petráš, Petr - Čejková, Darina - Doškař, Jiří
PY - 2017
TI - Characterization of two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus
PB - EMBL Heidelberg, Germany
CY - Germany
N1 - Nepřenášíme do RIV, výsledek má jen 1 stranu, podle metodiky M17+ musí mít stať ve sborníku min. 2 strany.
KW - ETB plasmid
KW - exfoliative toxin B
KW - phylogeny
KW - genome analysis
UR - https://www.embo-embl-symposia.org/symposia/2017/EES17-05/index.html
N2 - Staphylococcal epidermolytic diseases are caused by S. aureus strains producing exfoliative toxins A and B encoded by mobile genetic elements: plasmids and prophages. We analyzed various etb gene-positive plasmids isolated from the impetigo strains implicated in outbreaks of pemphigus neonatorum in Czech maternity hospitals. Most of the plasmids were related to archetypal plasmid pETBTY4. They shared a same core sequence, but they differed from each other in the content of additional DNA regions such as antibiotic resistance-encoding transposons. The ETB plasmids of this lineage were carried by strains of clonal complex CC121. Some of these strains also harbored exfoliative toxin A-encoding prophages. A novel distinct type of ETB plasmid originated from a prophageless impetigo strain was isolated and characterized in detail. Carrying conjugative cluster genes, as well as new variants of ETB and EDIN genes, it could be regarded as a source of a new lineage of ETB plasmids. Based on our findings, we have designed a helpful detection assay, which facilitates the precise identification of the all described types of ETB plasmids.
ER -
BOTKA, Tibor, Vladislava RŮŽIČKOVÁ, Karla SVOBODOVÁ, Roman PANTŮČEK, Petr PETRÁŠ, Darina ČEJKOVÁ a Jiří DOŠKAŘ. Characterization of two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. In Carolina Garcia Sabaté. \textit{EMBO $|$ EMBL Symposium: New Approaches and Concepts in Microbiology}. Germany: EMBL Heidelberg, Germany. s.~122. 2017.
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