Detailed Information on Publication Record
2017
Motility in blastogregarines (Apicomplexa): Native and drug-induced organisation of Siedleckia nematoides cytoskeletal elements
BARDŮNEK VALIGUROVÁ, Andrea, Naděžda VAŠKOVICOVÁ, Andrei DIAKIN, Gita PASKEROVA, Timur G. SIMDYANOV et. al.Basic information
Original name
Motility in blastogregarines (Apicomplexa): Native and drug-induced organisation of Siedleckia nematoides cytoskeletal elements
Authors
BARDŮNEK VALIGUROVÁ, Andrea (703 Slovakia, guarantor, belonging to the institution), Naděžda VAŠKOVICOVÁ (203 Czech Republic), Andrei DIAKIN (643 Russian Federation, belonging to the institution), Gita PASKEROVA (643 Russian Federation), Timur G. SIMDYANOV (643 Russian Federation) and Magdaléna KOVÁČIKOVÁ (703 Slovakia, belonging to the institution)
Edition
PLOS ONE, SAN FRANCISCO, Public Library of Science, 2017, 1932-6203
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10600 1.6 Biological sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.766
RIV identification code
RIV/00216224:14310/17:00094844
Organization unit
Faculty of Science
UT WoS
000404135800054
Keywords in English
Actin; tubulin; drug-induced changes; cytoskeleton; motility; Siedleckia nematoides
Tags
International impact, Reviewed
Změněno: 9/4/2018 14:46, Ing. Nicole Zrilić
Abstract
V originále
Recent studies on motility of Apicomplexa concur with the so-called glideosome concept applied for apicomplexan zoites, describing a unique mechanism of substrate-dependent gliding motility facilitated by a conserved form of actomyosin motor and subpellicular microtubules. In contrast, the gregarines and blastogregarines exhibit different modes and mechanisms of motility, correlating with diverse modifications of their cortex. This study focuses on the motility and cytoskeleton of the blastogregarine Siedleckia nematoides Caullery et Mesnil, 1898 parasitising the polychaete Scoloplos cf. armiger (Mu ¨ller, 1776). The blastogregarine moves independently on a solid substrate without any signs of gliding motility; the motility in a liquid environment (in both the attached and detached forms) rather resembles a sequence of pendular, twisting, undulation, and sometimes spasmodic movements. Despite the presence of key glideosome components such as pellicle consisting of the plasma membrane and the inner membrane complex, actin, myosin, subpellicular microtubules, micronemes and glycocalyx layer, the motility mechanism of S. nematoides differs from the glideosome machinery. Nevertheless, experimental assays using cytoskeletal probes proved that the polymerised forms of actin and tubulin play an essential role in the S. nematoides movement. Similar to Selenidium archigregarines, the subpellicular microtubules organised in several layers seem to be the leading motor structures in blastogregarine motility. The majority of the detected actin was stabilised in a polymerised form and appeared to be located beneath the inner membrane complex. The experimental data suggest the subpellicular microtubules to be associated with filamentous structures (= cross-linking protein complexes), presumably of actin nature.
Links
| GBP505/12/G112, research and development project |
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