KUNOVSKÝ, Lumír, Zdeněk KALA, Roman SVATOŇ, Milan DASTYCH, Radek KROUPA, Jiří DOLINA, Vladimír ČAN and Vladimír PROCHÁZKA. Transanální minimalne invazivní resekce rekta s totalni mezorektalni excizí po endoskopické mukóznf resekci (Transanal minimally invasive rectal resection with total mesorectal excision after endoscopic mucosal resection). Gastroenterologie a hepatologie. Praha: Ambit Media, 2017, vol. 71, No 3, p. 208-214. ISSN 1804-7874. Available from: https://dx.doi.org/10.14735/amgh2017208.
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Basic information
Original name Transanální minimalne invazivní resekce rekta s totalni mezorektalni excizí po endoskopické mukóznf resekci
Name in Czech Transanální minimalne invazivní resekce rekta s totalni mezorektalni excizí po endoskopické mukóznf resekci
Name (in English) Transanal minimally invasive rectal resection with total mesorectal excision after endoscopic mucosal resection
Authors KUNOVSKÝ, Lumír (203 Czech Republic, guarantor, belonging to the institution), Zdeněk KALA (203 Czech Republic, belonging to the institution), Roman SVATOŇ (703 Slovakia, belonging to the institution), Milan DASTYCH (203 Czech Republic, belonging to the institution), Radek KROUPA (203 Czech Republic, belonging to the institution), Jiří DOLINA (203 Czech Republic, belonging to the institution), Vladimír ČAN (703 Slovakia, belonging to the institution) and Vladimír PROCHÁZKA (203 Czech Republic, belonging to the institution).
Edition Gastroenterologie a hepatologie, Praha, Ambit Media, 2017, 1804-7874.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30219 Gastroenterology and hepatology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/17:00095648
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.14735/amgh2017208
Keywords (in Czech) chirurgie rekta; endoskopická mukózní resekce; karcinom rekta; totální mezorektální excize; transanální minimálně invazivní chirurgie
Keywords in English Endoscopic mucosal resection; Rectal cancer; Rectal surgery; Total mesorectal excision; Transanal minimally invasive surgery
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 22/3/2018 14:34.
Abstract
Karcinom rekta představuje závažný onkologický problém, jehož řešení vyžaduje multidisciplinární tým. V současné době tvoří karcinom rekta v ČR více než 1/4 ze všech nově diagnostikovaných nádorů kolorektálního karcinomu. Téměř 70 % kolorektálních karcinomů vzniká na podkladě adenomových polypů. Benigní léze typu adenomu či hyperplastického polypu lze řešit endoskopicky. Také u neinvazivních maligních lézí (omezené na sliznici) se endoskopická resekce považuje za dostatečnou. Za určitých kritérií může však být endoskopická lokální excize považována za plně kurativní výkon i u invazivního karcinomu (cut-off limit vrstva sm2). Při nepříznivém gradingu tumoru u invazivního karcinomu pronikajícího do submukózní vrstvy sm3 nelze nález řešit endoskopicky metodou endoskopické mukózní resekce (EMR) či endoskopické submukózní disekce a pacient je indikován k radikální chirurgické léčbě.
Abstract (in English)
Rectal cancer constitutes a serious oncological problem, and treatment of this disease involves a multidisciplinary team. Nowadays, rectal cancer constitutes more than a quarter of newly diagnosed colorectal cancers in the Czech Republic. Almost 70% of colorectal cancers develop from adenomatous polyps. Benign lesions such as adenoma or hyperplastic polyps can be treated endoscopically. In addition, in non-invasive malignant lesions (which are limited to the mucosa), endoscopic resection is considered curative. If certain criteria are met, endoscopic local excision can be considered a fully curative procedure, even in invasive cancer (cut-off limit: submucosa layer SM2). In patients with an unfavourable tumour grade, with carcinoma invading the submucosal layer (SM3), the cancer cannot be treated endoscopically by endoscopic mucosal resection (EMR) or endoscopic submucosal dissection and surgery is indicated. In some cases, endoscopic treatment can be inadequate and a surgical procedure has to be performed. During 2014-2015, four patients in our department underwent EMR to treat flat mucosal lesions 4-8 cm from the anal verge; however, local excision was not oncologically radical enough, and the patients were indicated for surgical resection. In these patients, a rectal resection with coloanal anastomosis was performed by transanal minimally invasive surgery (TAMIS), a new method that combines mini-invasive surgery with radical surgery resection without a permanent stoma, while meeting oncological radicality criteria. TAMIS can be beneficially used in patients after EMR if histology is promptly evaluated. Total mesorectal excision (TME), i.e., the removal of the fat coating surrounding the rectum along with its lymphatic nodes, has already become a standard surgical treatment for rectal cancer. TAMIS can be used for rectal resection with TME without the need for a stoma, even in low rectal cancer. Adverse histological results after EMR do not necessarily need to lead to an indication for rectal resection with a permanent stoma, but there is a possibility of intersphincteric resection with total lymphadenectomy.
Links
NV16-31765A, research and development projectName: Využití tkáňových/cirkulujících mikroRNA pro predikci léčebné odpovědi a zpřesnění restagingu karcinomu rekta po neoadjuvantní léčbě
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