J 2017

Multi-center machine learning in imaging psychiatry: A meta-model approach

DLUHOŠ, Petr, Daniel SCHWARZ, Wiepke CAHN, Neeltje van HAREN, René KAHN et. al.

Basic information

Original name

Multi-center machine learning in imaging psychiatry: A meta-model approach

Authors

DLUHOŠ, Petr (203 Czech Republic, guarantor, belonging to the institution), Daniel SCHWARZ (203 Czech Republic, belonging to the institution), Wiepke CAHN (528 Netherlands), Neeltje van HAREN (528 Netherlands), René KAHN (528 Netherlands), Filip ŠPANIEL (203 Czech Republic), Jiří HORÁČEK (203 Czech Republic), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Hugo SCHNACK (528 Netherlands)

Edition

NeuroImage, San Diego, Academic Press Inc Elsevier Science, 2017, 1053-8119

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.426

RIV identification code

RIV/00216224:14110/17:00097266

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.neuroimage.2017.03.027

UT WoS

000405460900002

Keywords in English

classification; combining models; first-episode schizophrenia; Machine learning; multi-center; prediction; support vector machines (SVM)

Tags

EL OK, podil

Tags

International impact, Reviewed
Změněno: 20/3/2018 17:37, Soňa Böhmová

Abstract

V originále

One of the biggest problems in automated diagnosis of psychiatric disorders from medical images is the lack of sufficiently large samples for training. Sample size is especially important in the case of highly heterogeneous disorders such as schizophrenia, where machine learning models built on relatively low numbers of subjects may suffer from poor generalizability. Via multicenter studies and consortium initiatives researchers have tried to solve this problem by combining data sets from multiple sites. The necessary sharing of (raw) data is, however, often hindered by legal and ethical issues. Moreover, in the case of very large samples, the computational complexity might become too large. The solution to this problem could be distributed learning. In this paper we investigated the possibility to create a meta-model by combining support vector machines (SVM) classifiers trained on the local datasets, without the need for sharing medical images or any other personal data. Validation was done in a 4-center setup comprising of 480 first-episode schizophrenia patients and healthy controls in total. We built SVM models to separate patients from controls based on three different kinds of imaging features derived from structural MRI scans, and compared models built on the joint multicenter data to the meta-models. The results showed that the combined meta-model had high similarity to the model built on all data pooled together and comparable classification performance on all three imaging features. Both similarity and performance was superior to that of the local models. We conclude that combining models is thus a viable alternative that facilitates data sharing and creating bigger and more informative models.

Links

LQ1601, research and development project
Name: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
Displayed: 2/11/2024 03:08