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@article{1386644,
author = {Liebregts, Max and Faber, Lothar and Jensen, Morten K. and Vriesendorp, Pieter A. and Januska, Jaroslav and Krejčí, Jan and Hansen, Peter R. and Seggewiss, Hubert and Horstkotte, Dieter and Adlova, Radka and Bundgaard, Henning and Berg, Jurriën M. ten and Veselka, Josef},
article_location = {New York},
article_number = {11},
doi = {http://dx.doi.org/10.1016/j.jcin.2017.03.030},
keywords = {alcohol septal ablation; hypertrophic cardiomyopathy; septal reduction therapy},
language = {eng},
issn = {1936-8798},
journal = {JACC - Cardiovascular Interventions},
title = {Outcomes of Alcohol Septal Ablation in Younger Patients With Obstructive Hypertrophic Cardiomyopathy},
volume = {10},
year = {2017}
}
TY - JOUR
ID - 1386644
AU - Liebregts, Max - Faber, Lothar - Jensen, Morten K. - Vriesendorp, Pieter A. - Januska, Jaroslav - Krejčí, Jan - Hansen, Peter R. - Seggewiss, Hubert - Horstkotte, Dieter - Adlova, Radka - Bundgaard, Henning - Berg, Jurriën M. ten - Veselka, Josef
PY - 2017
TI - Outcomes of Alcohol Septal Ablation in Younger Patients With Obstructive Hypertrophic Cardiomyopathy
JF - JACC - Cardiovascular Interventions
VL - 10
IS - 11
SP - 1135-1143
EP - 1135-1143
PB - Elsevier Science Inc.
SN - 19368798
KW - alcohol septal ablation
KW - hypertrophic cardiomyopathy
KW - septal reduction therapy
N2 - OBJECTIVES The aim of this study was to describe the safety and outcomes of alcohol septal ablation (ASA) in younger patients with obstructive hypertrophic cardiomyopathy. BACKGROUND The American College of Cardiology Foundation/American Heart Association guidelines reserve ASA for older patients and patients with serious comorbidities. Data on long-term age-specific outcomes after ASA are scarce. METHODS A total of 1,197 patients (mean age 58 +/- 14 years) underwent ASA for obstructive hypertrophic cardiomyopathy. Patients were divided into young (<= 50 years), middle-age (51 to 64 years), and older (>= 65 years) groups. RESULTS Thirty-day mortality and pacemaker implantation rates were lower in young compared with older patients (0.3% vs. 2%[p = 0.03] and 8% vs. 16%[p < 0.001], respectively). Ninety-five percent of young patients were in New York Heart Association functional class I or II at last follow-up. During a mean follow-up period of 5.4 +/- 4.2 years, 165 patients (14%) died. Annual mortality rates of young, middle-age, and older patients were 1%, 2%, and 5%, respectively (p < 0.01). Annual adverse arrhythmic event rates were similar in the 3 age groups at about 1%(p = 0.90). Independent predictors of mortality in young patients were age, female sex, and residual left ventricular outflow tract gradient. Additionally, young patients treated with >= 2.5 ml alcohol had a higher all-cause mortality rate (0.6% vs. 1.4% per year in patients treated with < 2.5 ml, p = 0.03). CONCLUSIONS ASA in younger patients with obstructive hypertrophic cardiomyopathy was safe and effective for relief of symptoms at long-term follow-up. The authors propose that the indication for ASA can be broadened to younger patients. (J Am Coll Cardiol Intv 2017;10:1134-43) (C) 2017 by the American College of Cardiology Foundation.
ER -
LIEBREGTS, Max, Lothar FABER, Morten K. JENSEN, Pieter A. VRIESENDORP, Jaroslav JANUSKA, Jan KREJČÍ, Peter R. HANSEN, Hubert SEGGEWISS, Dieter HORSTKOTTE, Radka ADLOVA, Henning BUNDGAARD, Jurri$\backslash$''en M. ten BERG and Josef VESELKA. Outcomes of Alcohol Septal Ablation in Younger Patients With Obstructive Hypertrophic Cardiomyopathy. \textit{JACC - Cardiovascular Interventions}. New York: Elsevier Science Inc., 2017, vol.~10, No~11, p.~1135-1143. ISSN~1936-8798. Available from: https://dx.doi.org/10.1016/j.jcin.2017.03.030.
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