Outcome of Alcohol Septal Ablation in Mildly Symptomatic
Patients With Hypertrophic Obstructive Cardiomyopathy: A
Long-Term Follow-Up Study Based on the Euro-Alcohol Septal
Ablation Registry

J 2017

Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry

VESELKA, Josef, Lothar FABER, Max LIEBREGTS, Robert COOPER, Jaroslav JANUSKA et. al.

Basic information

Original name

Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry

Authors

VESELKA, Josef (203 Czech Republic), Lothar FABER (276 Germany), Max LIEBREGTS (528 Netherlands), Robert COOPER (826 United Kingdom of Great Britain and Northern Ireland), Jaroslav JANUSKA (203 Czech Republic), Jan KREJČÍ (203 Czech Republic, guarantor, belonging to the institution), Thomas BARTEL (40 Austria), Maciej DABROWSKI (616 Poland), Peter Riis HANSEN (208 Denmark), Vibeke Marie ALMAAS (578 Norway), Hubert SEGGEWISS (276 Germany), Dieter HORSTKOTTE (276 Germany), Radka ADLOVA (203 Czech Republic), Henning BUNDGAARD (208 Denmark), Jurriën ten BERG (528 Netherlands), Rodney Hilton STABLES (826 United Kingdom of Great Britain and Northern Ireland) and Morten Kvistholm JENSEN (208 Denmark)

Edition

Journal of the American Heart Association, Hoboken, Wiley-Blackwell, 2017, 2047-9980

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.450

RIV identification code

RIV/00216224:14110/17:00097297

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1161/JAHA.117.005735

UT WoS

000404098600056

Keywords in English

ablation; hypertrophic cardiomyopathy; outcome

Abstract

V originále

Background-The long-term efficacy and safety of alcohol septal ablation (ASA) in patients with highly symptomatic hypertrophic obstructive cardiomyopathy has been demonstrated. The aim of this study was to evaluate the long-term outcomes of mildly symptomatic patients with hypertrophic obstructive cardiomyopathy treated with ASA. Methods and Results-We retrospectively evaluated consecutive patients enrolled in the Euro-ASA registry (1427 patients) and identified 161 patients (53 +/- 13 years; 27% women) who were mildly symptomatic (New York Heart Association [NYHA] class II) pre-ASA. The median (interquartile range) follow-up was 4.8 (1.7-8.5) years. The clinical outcome was assessed and compared with the age-and sex-matched general population. The 30-day mortality after ASA was 0.6% and the annual all-cause mortality rate was 1.7%, which was similar to the age-and sex-matched general population (P=0.62). A total of 141 (88%) patients had resting left ventricular outflow tract gradient at the last clinical checkup <= 30 mm Hg. Obstruction was reduced from 63 +/- 32 to 15 +/- 19 mm Hg (P<0.01), and the mean NYHA class decreased from 2.0 +/- 0 to 1.3 +/- 0.1 (P<0.01); 69%, 29%, and 2% of patients were in NYHA class I, II, and III at the last clinical checkup, respectively. Conclusions-Mildly symptomatic hypertrophic obstructive cardiomyopathy patients treated with ASA had sustained symptomatic and hemodynamic relief with a low risk of developing severe heart failure. Their survival is comparable to the general population.

Citovat

VESELKA, Josef, Lothar FABER, Max LIEBREGTS, Robert COOPER, Jaroslav JANUSKA, Jan KREJČÍ, Thomas BARTEL, Maciej DABROWSKI, Peter Riis HANSEN, Vibeke Marie ALMAAS, Hubert SEGGEWISS, Dieter HORSTKOTTE, Radka ADLOVA, Henning BUNDGAARD, Jurriën ten BERG, Rodney Hilton STABLES and Morten Kvistholm JENSEN. Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry. Journal of the American Heart Association. Hoboken: Wiley-Blackwell, 2017, vol. 6, No 5, p. 1-6. ISSN 2047-9980. Available from: https://dx.doi.org/10.1161/JAHA.117.005735.

@article{1386646,
   author = {Veselka, Josef and Faber, Lothar and Liebregts, Max and Cooper, Robert and Januska, Jaroslav and Krejčí, Jan and Bartel, Thomas and Dabrowski, Maciej and Hansen, Peter Riis and Almaas, Vibeke Marie and Seggewiss, Hubert and Horstkotte, Dieter and Adlova, Radka and Bundgaard, Henning and Berg, Jurriën ten and Stables, Rodney Hilton and Jensen, Morten Kvistholm},
   article_location = {Hoboken},
   article_number = {5},
   doi = {http://dx.doi.org/10.1161/JAHA.117.005735},
   keywords = {ablation; hypertrophic cardiomyopathy; outcome},
   language = {eng},
   issn = {2047-9980},
   journal = {Journal of the American Heart Association},
   title = {Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry},
   volume = {6},
   year = {2017}
}

TY  - JOUR
ID  - 1386646
AU  - Veselka, Josef - Faber, Lothar - Liebregts, Max - Cooper, Robert - Januska, Jaroslav - Krejčí, Jan - Bartel, Thomas - Dabrowski, Maciej - Hansen, Peter Riis - Almaas, Vibeke Marie - Seggewiss, Hubert - Horstkotte, Dieter - Adlova, Radka - Bundgaard, Henning - Berg, Jurriën ten - Stables, Rodney Hilton - Jensen, Morten Kvistholm
PY  - 2017
TI  - Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry
JF  - Journal of the American Heart Association
VL  - 6
IS  - 5
SP  - 1-6
EP  - 1-6
PB  - Wiley-Blackwell
SN  - 20479980
KW  - ablation
KW  - hypertrophic cardiomyopathy
KW  - outcome
N2  - Background-The long-term efficacy and safety of alcohol septal ablation (ASA) in patients with highly symptomatic hypertrophic obstructive cardiomyopathy has been demonstrated. The aim of this study was to evaluate the long-term outcomes of mildly symptomatic patients with hypertrophic obstructive cardiomyopathy treated with ASA. Methods and Results-We retrospectively evaluated consecutive patients enrolled in the Euro-ASA registry (1427 patients) and identified 161 patients (53 +/- 13 years; 27% women) who were mildly symptomatic (New York Heart Association [NYHA] class II) pre-ASA. The median (interquartile range) follow-up was 4.8 (1.7-8.5) years. The clinical outcome was assessed and compared with the age-and sex-matched general population. The 30-day mortality after ASA was 0.6% and the annual all-cause mortality rate was 1.7%, which was similar to the age-and sex-matched general population (P=0.62). A total of 141 (88%) patients had resting left ventricular outflow tract gradient at the last clinical checkup <= 30 mm Hg. Obstruction was reduced from 63 +/- 32 to 15 +/- 19 mm Hg (P<0.01), and the mean NYHA class decreased from 2.0 +/- 0 to 1.3 +/- 0.1 (P<0.01); 69%, 29%, and 2% of patients were in NYHA class I, II, and III at the last clinical checkup, respectively. Conclusions-Mildly symptomatic hypertrophic obstructive cardiomyopathy patients treated with ASA had sustained symptomatic and hemodynamic relief with a low risk of developing severe heart failure. Their survival is comparable to the general population.
ER  -

VESELKA, Josef, Lothar FABER, Max LIEBREGTS, Robert COOPER, Jaroslav JANUSKA, Jan KREJČÍ, Thomas BARTEL, Maciej DABROWSKI, Peter Riis HANSEN, Vibeke Marie ALMAAS, Hubert SEGGEWISS, Dieter HORSTKOTTE, Radka ADLOVA, Henning BUNDGAARD, Jurri$\backslash$''en ten BERG, Rodney Hilton STABLES and Morten Kvistholm JENSEN. Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry. \textit{Journal of the American Heart Association}. Hoboken: Wiley-Blackwell, 2017, vol.~6, No~5, p.~1-6. ISSN~2047-9980. Available from: https://dx.doi.org/10.1161/JAHA.117.005735.

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