PALEČEK, Jan, Stephan GRUBER, Lucie VONDROVÁ, Marek ADAMUS, Kateřina ZÁBRADY, Lenka JURČIŠINOVÁ, Saskia N van der CRABBEN, Marije P HENNUS, Grant MCGREGOR, Deborah I RITTER, Alan R LEHMANN, Antony W OLIVER, Barbora KOZLÍKOVÁ, Sharon E PLON, Johanne M MURRAY a Gijs van HAAFTEN. Evolution and functions of SMC complexes: new SMC5/6 insights. In Central European Genome Stability and Damage Meeting. 2016.
Další formáty:   BibTeX LaTeX RIS
Základní údaje
Originální název Evolution and functions of SMC complexes: new SMC5/6 insights
Název anglicky Evolution and functions of SMC complexes: new SMC5/6 insights
Autoři PALEČEK, Jan, Stephan GRUBER, Lucie VONDROVÁ, Marek ADAMUS, Kateřina ZÁBRADY, Lenka JURČIŠINOVÁ, Saskia N van der CRABBEN, Marije P HENNUS, Grant MCGREGOR, Deborah I RITTER, Alan R LEHMANN, Antony W OLIVER, Barbora KOZLÍKOVÁ, Sharon E PLON, Johanne M MURRAY a Gijs van HAAFTEN.
Vydání Central European Genome Stability and Damage Meeting, 2016.
Další údaje
Typ výsledku Vyžádané přednášky
Utajení není předmětem státního či obchodního tajemství
Změnil Změnil: doc. Mgr. Jan Paleček, Dr. rer. nat., učo 38623. Změněno: 9. 8. 2017 16:40.
Anotace
The SMC (structure maintenance of chromosome) complexes are conserved from bacteria to humans (SMC/ScpAB and MukBEF in prokaryotes; cohesin, condensin and SMC5/6 in eukaryotes). They are critical for DNA replication, chromosome compaction and segregation, genome maintenance, and regulation of gene expression. We described marked structural similarities between bacterial SMC/ScpAB and eukaryotic SMC5/6 complexes (particularly their kite subunits). We discovered several important features of SMC5/6 kite subunits: their role in structural organization of the SMC5/6 complex, their DNA-binding ability, their evolution from bacteria to novel mammalian MAGE protein superfamily and new chromosome breakage syndrome associated with human Nse3-kite subunit mutations.
Anotace anglicky
The SMC (structure maintenance of chromosome) complexes are conserved from bacteria to humans (SMC/ScpAB and MukBEF in prokaryotes; cohesin, condensin and SMC5/6 in eukaryotes). They are critical for DNA replication, chromosome compaction and segregation, genome maintenance, and regulation of gene expression. We described marked structural similarities between bacterial SMC/ScpAB and eukaryotic SMC5/6 complexes (particularly their kite subunits). We discovered several important features of SMC5/6 kite subunits: their role in structural organization of the SMC5/6 complex, their DNA-binding ability, their evolution from bacteria to novel mammalian MAGE protein superfamily and new chromosome breakage syndrome associated with human Nse3-kite subunit mutations.
Návaznosti
GA13-00774S, projekt VaVNázev: Úloha proteinů Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikační vidlice
Investor: Grantová agentura ČR, Úloha proteinu Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikacní vidlice
MUNI/M/0822/2015, interní kód MUNázev: Expressive Visualization of Protein Complexes
Investor: Masarykova univerzita, Expressive Visualization of Protein Complexes, INTERDISCIPLINARY - Mezioborové výzkumné projekty
VytisknoutZobrazeno: 19. 3. 2024 06:34