Evolution and functions of SMC complexes: new SMC5/6 insights

p 2016

Evolution and functions of SMC complexes: new SMC5/6 insights

PALEČEK, Jan, Stephan GRUBER, Lucie VONDROVÁ, Marek ADAMUS, Kateřina ZÁBRADY et. al.

Basic information

Original name

Evolution and functions of SMC complexes: new SMC5/6 insights

Name (in English)

Evolution and functions of SMC complexes: new SMC5/6 insights

Authors

Edition

Central European Genome Stability and Damage Meeting, 2016

Other information

Type of outcome

Vyžádané přednášky

Confidentiality degree

není předmětem státního či obchodního tajemství

Změněno: 9/8/2017 16:40, doc. Mgr. Jan Paleček, Dr. rer. nat.

Abstract

ORIG EN

V originále

The SMC (structure maintenance of chromosome) complexes are conserved from bacteria to humans (SMC/ScpAB and MukBEF in prokaryotes; cohesin, condensin and SMC5/6 in eukaryotes). They are critical for DNA replication, chromosome compaction and segregation, genome maintenance, and regulation of gene expression. We described marked structural similarities between bacterial SMC/ScpAB and eukaryotic SMC5/6 complexes (particularly their kite subunits). We discovered several important features of SMC5/6 kite subunits: their role in structural organization of the SMC5/6 complex, their DNA-binding ability, their evolution from bacteria to novel mammalian MAGE protein superfamily and new chromosome breakage syndrome associated with human Nse3-kite subunit mutations.

In English

Links

GA13-00774S, research and development project

Name: Úloha proteinů Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikační vidlice

Investor: Czech Science Foundation

MUNI/M/0822/2015, interní kód MU

Name: Expressive Visualization of Protein Complexes

Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects

Citovat

PALEČEK, Jan, Stephan GRUBER, Lucie VONDROVÁ, Marek ADAMUS, Kateřina ZÁBRADY, Lenka JURČIŠINOVÁ, Saskia N van der CRABBEN, Marije P HENNUS, Grant MCGREGOR, Deborah I RITTER, Alan R LEHMANN, Antony W OLIVER, Barbora KOZLÍKOVÁ, Sharon E PLON, Johanne M MURRAY and Gijs van HAAFTEN. Evolution and functions of SMC complexes: new SMC5/6 insights. In Central European Genome Stability and Damage Meeting. 2016.

@misc{1386682,
   author = {Paleček, Jan and Gruber, Stephan and Vondrová, Lucie and Adamus, Marek and Zábrady, Kateřina and Jurčišinová, Lenka and Crabben, Saskia N van der and Hennus, Marije P and McGregor, Grant and Ritter, Deborah I and Lehmann, Alan R and Oliver, Antony W and Kozlíková, Barbora and Plon, Sharon E and Murray, Johanne M and Haaften, Gijs van},
   booktitle = {Central European Genome Stability and Damage Meeting},
   title = {Evolution and functions of SMC complexes: new SMC5/6 insights},
   year = {2016}
}

TY  - SLIDE
ID  - 1386682
AU  - Paleček, Jan - Gruber, Stephan - Vondrová, Lucie - Adamus, Marek - Zábrady, Kateřina - Jurčišinová, Lenka - Crabben, Saskia N van der - Hennus, Marije P - McGregor, Grant - Ritter, Deborah I - Lehmann, Alan R - Oliver, Antony W - Kozlíková, Barbora - Plon, Sharon E - Murray, Johanne M - Haaften, Gijs van
PY  - 2016
TI  - Evolution and functions of SMC complexes: new SMC5/6 insights
N2  - The SMC (structure maintenance of chromosome) complexes are conserved from bacteria to humans (SMC/ScpAB and MukBEF in prokaryotes; cohesin, condensin and SMC5/6 in eukaryotes). They are critical for DNA replication, chromosome compaction and segregation, genome maintenance, and regulation of gene expression. We described marked structural similarities between bacterial SMC/ScpAB and eukaryotic SMC5/6 complexes (particularly their kite subunits). We discovered several important features of SMC5/6 kite subunits: their role in structural organization of the SMC5/6 complex, their DNA-binding ability, their evolution from bacteria to novel mammalian MAGE protein superfamily and new chromosome breakage syndrome associated with human Nse3-kite subunit mutations.
ER  -

PALEČEK, Jan, Stephan GRUBER, Lucie VONDROVÁ, Marek ADAMUS, Kateřina ZÁBRADY, Lenka JURČIŠINOVÁ, Saskia N van der CRABBEN, Marije P HENNUS, Grant MCGREGOR, Deborah I RITTER, Alan R LEHMANN, Antony W OLIVER, Barbora KOZLÍKOVÁ, Sharon E PLON, Johanne M MURRAY and Gijs van HAAFTEN. Evolution and functions of SMC complexes: new SMC5/6 insights. In \textit{Central European Genome Stability and Damage Meeting}. 2016.

Detailed Information on Publication Record