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@article{1386743, author = {Moratalla, Rosario and Khairnar, Amit Suresh and Simola, Nicola and Granado, Noelia and GarciaandMontes, Jose Ruben and Porceddu, Pier Francesca and Tizabi, Yousef and Costa, Giulia and Morelli, Micaela}, article_location = {OXFORD}, article_number = {August}, doi = {http://dx.doi.org/10.1016/j.pneurobio.2015.09.011}, keywords = {Dopamine; Ecstasy; Methamphetamine; METH; MDMA; Mouse; Neurodegeneration; Neuroinflammation neurotoxicity; Non-human primate; Rat}, language = {eng}, issn = {0301-0082}, journal = {PROGRESS IN NEUROBIOLOGY}, title = {Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms}, url = {http://www.sciencedirect.com/science/article/pii/S0301008215001008?via%3Dihub}, volume = {155}, year = {2017} }
TY - JOUR ID - 1386743 AU - Moratalla, Rosario - Khairnar, Amit Suresh - Simola, Nicola - Granado, Noelia - Garcia-Montes, Jose Ruben - Porceddu, Pier Francesca - Tizabi, Yousef - Costa, Giulia - Morelli, Micaela PY - 2017 TI - Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms JF - PROGRESS IN NEUROBIOLOGY VL - 155 IS - August SP - 149-170 EP - 149-170 PB - PERGAMON-ELSEVIER SCIENCE LTD SN - 03010082 KW - Dopamine KW - Ecstasy KW - Methamphetamine KW - METH KW - MDMA KW - Mouse KW - Neurodegeneration KW - Neuroinflammation neurotoxicity KW - Non-human primate KW - Rat UR - http://www.sciencedirect.com/science/article/pii/S0301008215001008?via%3Dihub L2 - http://www.sciencedirect.com/science/article/pii/S0301008215001008?via%3Dihub N2 - Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and nonhuman primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse. (C) 2015 Elsevier Ltd. All rights reserved. ER -
MORATALLA, Rosario, Amit Suresh KHAIRNAR, Nicola SIMOLA, Noelia GRANADO, Jose Ruben GARCIA-MONTES, Pier Francesca PORCEDDU, Yousef TIZABI, Giulia COSTA and Micaela MORELLI. Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms. \textit{PROGRESS IN NEUROBIOLOGY}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2017, vol.~155, August, p.~149-170. ISSN~0301-0082. Available from: https://dx.doi.org/10.1016/j.pneurobio.2015.09.011.
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