MORATALLA, Rosario, Amit Suresh KHAIRNAR, Nicola SIMOLA, Noelia GRANADO, Jose Ruben GARCIA-MONTES, Pier Francesca PORCEDDU, Yousef TIZABI, Giulia COSTA and Micaela MORELLI. Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms. PROGRESS IN NEUROBIOLOGY. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2017, vol. 155, August, p. 149-170. ISSN 0301-0082. Available from: https://dx.doi.org/10.1016/j.pneurobio.2015.09.011.
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Basic information
Original name Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms
Authors MORATALLA, Rosario (724 Spain), Amit Suresh KHAIRNAR (356 India, guarantor, belonging to the institution), Nicola SIMOLA (380 Italy), Noelia GRANADO (724 Spain), Jose Ruben GARCIA-MONTES (724 Spain), Pier Francesca PORCEDDU (380 Italy), Yousef TIZABI (840 United States of America), Giulia COSTA (380 Italy) and Micaela MORELLI (380 Italy).
Edition PROGRESS IN NEUROBIOLOGY, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2017, 0301-0082.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30103 Neurosciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 14.163
RIV identification code RIV/00216224:14740/17:00097313
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.pneurobio.2015.09.011
UT WoS 000403544300009
Keywords in English Dopamine; Ecstasy; Methamphetamine; METH; MDMA; Mouse; Neurodegeneration; Neuroinflammation neurotoxicity; Non-human primate; Rat
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 16/5/2018 10:50.
Abstract
Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and nonhuman primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse. (C) 2015 Elsevier Ltd. All rights reserved.
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