| TOSUN, S., A. BATIREL, A.I. OLUK, F. AKSOY, E. PUCA, F. BENEZIT, S. URAL, S. NAYMAN-ALPAT, T. YAMAZHAN, V. KOKSALDI-MOTOR, R. TEKIN, E. PARLAK, P. TATTEVIN, K. KART-YASAR, R. GUNER, A. BASTUG, M. MERIC-KOC, S. ONCU, A. SAGMAK-TARTAR, A. DENK, F. PEHLIVANOGLU, G. SENGOZ, S.M. SORENSEN, G. CELEBI, Lenka FAŠANEKOVÁ, H. GEDIK, S. DIRGEN-CAYLAK, A. ESMAOGLU, S. EROL, Y. CAG, E. KARAGOZ, A. INAN and H. ERDEM. Tetanus in adults: results of the multicenter ID-IRI study. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. NEW YORK: SPRINGER, 2017, vol. 36, No 8, p. 1455-1462. ISSN 0934-9723. Available from: https://dx.doi.org/10.1007/s10096-017-2954-3. |
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@article{1387282,
author = {Tosun, S. and Batirel, A. and Oluk, A.I. and Aksoy, F. and Puca, E. and Benezit, F. and Ural, S. and NaymanandAlpat, S. and Yamazhan, T. and KoksaldiandMotor, V. and Tekin, R. and Parlak, E. and Tattevin, P. and KartandYasar, K. and Guner, R. and Bastug, A. and MericandKoc, M. and Oncu, S. and SagmakandTartar, A. and Denk, A. and Pehlivanoglu, F. and Sengoz, G. and Sorensen, S.M. and Celebi, G. and Fašaneková, Lenka and Gedik, H. and DirgenandCaylak, S. and Esmaoglu, A. and Erol, S. and Cag, Y. and Karagoz, E. and Inan, A. and Erdem, H.},
article_location = {NEW YORK},
article_number = {8},
doi = {http://dx.doi.org/10.1007/s10096-017-2954-3},
keywords = {tetanus},
language = {eng},
issn = {0934-9723},
journal = {EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES},
title = {Tetanus in adults: results of the multicenter ID-IRI study},
volume = {36},
year = {2017}
}
TY - JOUR
ID - 1387282
AU - Tosun, S. - Batirel, A. - Oluk, A.I. - Aksoy, F. - Puca, E. - Benezit, F. - Ural, S. - Nayman-Alpat, S. - Yamazhan, T. - Koksaldi-Motor, V. - Tekin, R. - Parlak, E. - Tattevin, P. - Kart-Yasar, K. - Guner, R. - Bastug, A. - Meric-Koc, M. - Oncu, S. - Sagmak-Tartar, A. - Denk, A. - Pehlivanoglu, F. - Sengoz, G. - Sorensen, S.M. - Celebi, G. - Fašaneková, Lenka - Gedik, H. - Dirgen-Caylak, S. - Esmaoglu, A. - Erol, S. - Cag, Y. - Karagoz, E. - Inan, A. - Erdem, H.
PY - 2017
TI - Tetanus in adults: results of the multicenter ID-IRI study
JF - EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
VL - 36
IS - 8
SP - 1455-1462
EP - 1455-1462
PB - SPRINGER
SN - 09349723
KW - tetanus
N2 - Tetanus is an acute, severe infection caused by a neurotoxin secreting bacterium. Various prognostic factors affecting mortality in tetanus patients have been described in the literature. In this study, we aimed to analyze the factors affecting mortality in hospitalized tetanus patients in a large case series. This retrospective multicenter study pooled data of tetanus patients from 25 medical centers. The hospitals participating in this study were the collaborating centers of the Infectious Diseases International Research Initiative (ID-IRI). Only adult patients over the age of 15 years with tetanus were included. The diagnosis of tetanus was made by the clinicians at the participant centers. Izmir Bozyaka Education and Research Hospital's Review Board approved the study. Prognostic factors were analyzed by using the multivariate regression analysis method. In this study, 117 adult patients with tetanus were included. Of these, 79 (67.5%) patients survived and 38 (32.5%) patients died. Most of the deaths were observed in patients >60 years of age (60.5%). Generalized type of tetanus, presence of pain at the wound area, presence of generalized spasms, leukocytosis, high alanine aminotransferase (ALT) and C-reactive protein (CRP) values on admission, and the use of equine immunoglobulins in the treatment were found to be statistically associated with mortality (p < 0.05 for all). Here, we describe the prognostic factors for mortality in tetanus. Immunization seems to be the most critical point, considering the advanced age of our patients. A combination of laboratory and clinical parameters indicates mortality. Moreover, human immunoglobulins should be preferred over equine sera to increase survival.
ER -
TOSUN, S., A. BATIREL, A.I. OLUK, F. AKSOY, E. PUCA, F. BENEZIT, S. URAL, S. NAYMAN-ALPAT, T. YAMAZHAN, V. KOKSALDI-MOTOR, R. TEKIN, E. PARLAK, P. TATTEVIN, K. KART-YASAR, R. GUNER, A. BASTUG, M. MERIC-KOC, S. ONCU, A. SAGMAK-TARTAR, A. DENK, F. PEHLIVANOGLU, G. SENGOZ, S.M. SORENSEN, G. CELEBI, Lenka FAŠANEKOVÁ, H. GEDIK, S. DIRGEN-CAYLAK, A. ESMAOGLU, S. EROL, Y. CAG, E. KARAGOZ, A. INAN and H. ERDEM. Tetanus in adults: results of the multicenter ID-IRI study. \textit{EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY \&{}amp; INFECTIOUS DISEASES}. NEW YORK: SPRINGER, 2017, vol.~36, No~8, p.~1455-1462. ISSN~0934-9723. Available from: https://dx.doi.org/10.1007/s10096-017-2954-3.
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