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@article{1387519,
author = {Delgado, Julio and Doubek, Michael and Baumann, Tycho and Kotašková, Jana and Molica, Stefano and Mozas, Pablo and RivasandDelgado, Alfredo and Morabito, Fortunato and Pospíšilová, Šárka and Montserrat, Emili},
article_location = {Hoboken},
article_number = {4},
doi = {http://dx.doi.org/10.1002/ajh.24660},
keywords = {INDEPENDENT PREDICTOR; MULTIVARIATE-ANALYSIS; GENOMIC ABERRATIONS; SURVIVAL ANALYSIS; CD38 EXPRESSION; DOUBLING TIME; 1ST TREATMENT; TRIAL; INDEX; GENE},
language = {eng},
issn = {0361-8609},
journal = {American Journal of Hematology},
title = {Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI},
url = {http://onlinelibrary.wiley.com/doi/10.1002/ajh.24660/abstract;jsessionid=539A218FD2C364B21D3AA16CBF9E3418.f03t03},
volume = {92},
year = {2017}
}
TY - JOUR
ID - 1387519
AU - Delgado, Julio - Doubek, Michael - Baumann, Tycho - Kotašková, Jana - Molica, Stefano - Mozas, Pablo - Rivas-Delgado, Alfredo - Morabito, Fortunato - Pospíšilová, Šárka - Montserrat, Emili
PY - 2017
TI - Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI
JF - American Journal of Hematology
VL - 92
IS - 4
SP - 375-380
EP - 375-380
PB - John Wiley & Sons
SN - 03618609
KW - INDEPENDENT PREDICTOR
KW - MULTIVARIATE-ANALYSIS
KW - GENOMIC ABERRATIONS
KW - SURVIVAL ANALYSIS
KW - CD38 EXPRESSION
KW - DOUBLING TIME
KW - 1ST TREATMENT
KW - TRIAL
KW - INDEX
KW - GENE
UR - http://onlinelibrary.wiley.com/doi/10.1002/ajh.24660/abstract;jsessionid=539A218FD2C364B21D3AA16CBF9E3418.f03t03
L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajh.24660/abstract;jsessionid=539A218FD2C364B21D3AA16CBF9E3418.f03t03
N2 - Rai and Binet staging systems are important to predict the outcome of patients with chronic lymphocytic leukemia (CLL) but do not reflect the biologic diversity of the disease nor predict response to therapy, which ultimately shape patients' outcome. We devised a biomarkers-only CLL prognostic system based on the two most important prognostic parameters in CLL (i.e., IGHV mutational status and fluorescence in situ hybridization [FISH] cytogenetics), separating three different risk groups: (1) low-risk (mutated IGHV+no adverse FISH cytogenetics [del(17p), del(11q)]); (2) intermediate-risk (either unmutated IGHV or adverse FISH cytogenetics) and (3) high-risk (unmutated IGHV+adverse FISH cytogenetics). In 524 unselected subjects with CLL, the 10-year overall survival was 82% (95% CI 76%-88%), 52% (45%-62%), and 27% (17%-42%) for the low-, intermediate-, and high-risk groups, respectively. Patients with low-risk comprised around 50% of the series and had a life expectancy comparable to the general population. The prognostic model was fully validated in two independent cohorts, including 417 patients representative of general CLL population and 337 patients with Binet stage A CLL. The model had a similar discriminatory value as the CLL-IPI. Moreover, it applied to all patients with CLL independently of age, and separated patients with different risk within Rai or Binet clinical stages. The biomarkers-only CLL prognostic system presented here simplifies the CLL-IPI and could be useful in daily practice and to stratify patients in clinical trials.
ER -
DELGADO, Julio, Michael DOUBEK, Tycho BAUMANN, Jana KOTAŠKOVÁ, Stefano MOLICA, Pablo MOZAS, Alfredo RIVAS-DELGADO, Fortunato MORABITO, Šárka POSPÍŠILOVÁ and Emili MONTSERRAT. Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI. \textit{American Journal of Hematology}. Hoboken: John Wiley \&{} Sons, 2017, vol.~92, No~4, p.~375-380. ISSN~0361-8609. Available from: https://dx.doi.org/10.1002/ajh.24660.
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