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@article{1387521,
author = {Plešingerová, Hana and Librova, Zuzana and Plevová, Karla and Libra, Antonín and Tichý, Boris and Skuhrová Francová, Hana and Vrbacky, Filip and Smolej, Lukáš and Mayer, Jiří and Bryja, Vítězslav and Doubek, Michael and Pospíšilová, Šárka},
article_location = {Oxon},
article_number = {1},
doi = {http://dx.doi.org/10.1080/10428194.2016.1180690},
keywords = {Chronic lymphocytic leukemia; COBLL1; IGHV mutational status; LPL; prognosis; ZAP70},
language = {eng},
issn = {1042-8194},
journal = {LEUKEMIA & LYMPHOMA},
title = {COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status},
url = {http://www.tandfonline.com/doi/full/10.1080/10428194.2016.1180690},
volume = {58},
year = {2017}
}
TY - JOUR
ID - 1387521
AU - Plešingerová, Hana - Librova, Zuzana - Plevová, Karla - Libra, Antonín - Tichý, Boris - Skuhrová Francová, Hana - Vrbacky, Filip - Smolej, Lukáš - Mayer, Jiří - Bryja, Vítězslav - Doubek, Michael - Pospíšilová, Šárka
PY - 2017
TI - COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status
JF - LEUKEMIA & LYMPHOMA
VL - 58
IS - 1
SP - 70-79
EP - 70-79
PB - TAYLOR & FRANCIS LTD
SN - 10428194
KW - Chronic lymphocytic leukemia
KW - COBLL1
KW - IGHV mutational status
KW - LPL
KW - prognosis
KW - ZAP70
UR - http://www.tandfonline.com/doi/full/10.1080/10428194.2016.1180690
L2 - http://www.tandfonline.com/doi/full/10.1080/10428194.2016.1180690
N2 - The clinical course of chronic lymphocytic leukemia (CLL) is highly variable. Patients with unmutated IGHV (U-CLL) usually progress rapidly, whereas patients with mutated IGHV (M-CLL) have a more indolent disease. The expression of several genes correlates closely with the IGHV mutational status and could be used to assess prognosis in CLL. We analyzed the prognostic relevance of COBLL1, LPL, and ZAP70 gene expression, which correlated with IGHV mutational status (p< 0.0001), in 117 CLL patients and established a prognostic parameter dividing the tested cohort according to the disease aggressiveness. Our prognostic parameter was validated on an independent cohort of 161 CLL patients and achieved a high accuracy (94%). Patients divided according to the prognostic parameter differ in overall survival and time to first treatment (p< 0.0001, HR = 2.300/5.970, 95% CI: 1.587-3.450/4.621-15.86). Our approach provides a reliable alternative method to prognosis assessment via IGHV mutational status analysis.
ER -
PLEŠINGEROVÁ, Hana, Zuzana LIBROVA, Karla PLEVOVÁ, Antonín LIBRA, Boris TICHÝ, Hana SKUHROVÁ FRANCOVÁ, Filip VRBACKY, Lukáš SMOLEJ, Jiří MAYER, Vítězslav BRYJA, Michael DOUBEK a Šárka POSPÍŠILOVÁ. COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status. \textit{LEUKEMIA \&{} LYMPHOMA}. Oxon: TAYLOR \&{} FRANCIS LTD, roč.~58, č.~1, s.~70-79. ISSN~1042-8194. doi:10.1080/10428194.2016.1180690. 2017.
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