BHAT, Satish S., Vidyanand K. REVANKAR, Ayesha KHAN, Rahul V. PINJARI and Marek NEČAS. Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery. Chemistry - An Asian Journal. WEINHEIM: WILEY-V C H VERLAG GMBH, 2017, vol. 12, No 2, p. 254-264. ISSN 1861-4728. Available from: https://dx.doi.org/10.1002/asia.201601515.
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Basic information
Original name Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery
Authors BHAT, Satish S. (356 India), Vidyanand K. REVANKAR (356 India), Ayesha KHAN (356 India), Rahul V. PINJARI (356 India) and Marek NEČAS (203 Czech Republic, guarantor, belonging to the institution).
Edition Chemistry - An Asian Journal, WEINHEIM, WILEY-V C H VERLAG GMBH, 2017, 1861-4728.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10402 Inorganic and nuclear chemistry
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.692
RIV identification code RIV/00216224:14310/17:00097387
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1002/asia.201601515
UT WoS 000393434200014
Keywords in English DNA; electrochemistry; luminescence; photochemistry; ruthenium
Tags CF SAXS, NZ, rivok
Tags International impact, Reviewed
Changed by Changed by: Ing. Nicole Zrilić, učo 240776. Changed: 6/4/2018 15:28.
Abstract
Two new luminescent ruthenium(II) polypyridyl complexes, [Ru(bpy)(2)(tpt-phen)]Cl-2 (1; bpy=2,2'-bipyridine, tpt-phen=triptycenyl-1,10-phenanthroline) and [Ru(phen)(2)(tpt-phen)]Cl-2 (2; phen=1,10-phenanthroline), have been developed as potential nonviral vectors for DNA delivery. Photophysical and electrochemical properties of the complexes have been investigated and corroborated with electronic structure calculations. DNA condensation by these complexes has been investigated by UV/Vis and emission spectroscopy, circular dichroism spectroscopy, atomic force microscopy, dynamic light scattering, confocal microscopy, and electrophoretic mobility studies. These complexes interact with DNA and efficiently condense DNA into globular nanoparticles that are taken up efficiently by HeLa cells. DNA cleavage inability and biocompatibility of complexes have been explored. Both complexes have good gene transfection abilities.
Links
LM2015043, research and development projectName: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)
Investor: Ministry of Education, Youth and Sports of the CR
PrintDisplayed: 27/4/2024 21:27