Detailed Information on Publication Record
2017
Role of Primary Cilia in Odontogenesis
HAMPL, Marek, P. CELA, H.L. SZABO-ROGERS, Michaela BOSÁKOVÁ, H. DOSEDELOVA et. al.Basic information
Original name
Role of Primary Cilia in Odontogenesis
Authors
HAMPL, Marek (203 Czech Republic, belonging to the institution), P. CELA (203 Czech Republic), H.L. SZABO-ROGERS (840 United States of America), Michaela BOSÁKOVÁ (203 Czech Republic), H. DOSEDELOVA (203 Czech Republic), Pavel KREJČÍ (203 Czech Republic, belonging to the institution) and marcela BUCHTOVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Journal of Dental Research, THOUSAND OAKS, CA USA, SAGE PUBLICATIONS INC, 2017, 0022-0345
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30208 Dentistry, oral surgery and medicine
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 5.383
RIV identification code
RIV/00216224:14310/17:00094911
Organization unit
Faculty of Science
UT WoS
000406054800001
Keywords in English
craniofacial anomalies; growth/development; mineralized tissue/development; odontoblast(s); oral pathology; signal transduction
Tags
International impact, Reviewed
Změněno: 11/4/2018 14:17, Ing. Nicole Zrilić
Abstract
V originále
Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues. The cilia are present when interactions between both the epithelium and mesenchyme are required for normal morphogenesis. As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue-producing cells. Here, we summarize the current evidence for the localization of primary cilia in dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies.
Links
| GA17-14886S, research and development project |
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