Detailed Information on Publication Record
2017
Recent Findings of the Types of Programmed Cell Death
BORYS, Sylwia, Ronza KHOZMI, Wieslawa KRANS, Artur BRYJA, Marta DYSZKIEWICZ-KONWIŃSKA et. al.Basic information
Original name
Recent Findings of the Types of Programmed Cell Death
Authors
BORYS, Sylwia (616 Poland), Ronza KHOZMI (616 Poland), Wieslawa KRANS (616 Poland), Artur BRYJA (616 Poland), Marta DYSZKIEWICZ-KONWIŃSKA (616 Poland), Michal JEŠETA (203 Czech Republic, guarantor, belonging to the institution) and Bartosz KEMPISTY (616 Poland)
Edition
Advances in Cell Biology, Warsaw, Polskie towarzystwo anatomiczne, 2017, 0324-833X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30214 Obstetrics and gynaecology
Country of publisher
Poland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.147
RIV identification code
RIV/00216224:14110/17:00097424
Organization unit
Faculty of Medicine
Keywords in English
apoptosis; mitochondrial apoptosis pathway; necrosis; receptor-dependent apotposis; pathway
Tags
Tags
International impact, Reviewed
Změněno: 20/3/2018 16:29, Soňa Böhmová
Abstract
V originále
Cell death plays an important role in maintaining the homeostasis of multicellular organisms. It can occur in a controlled manner by apoptosis or autophagy. Cell death which occurs regardless of regulatory factors include necrosis, mitotic catastrophe or oncosis. Apoptosis and necrosis are cellular process that leads to cell death. However their mechanisms are different, although factors triggering them can be similar. Necrosis and apoptosis have many different characteristics in terms of biochemistry and morphology. There are two main pathways of apoptosis induction signal: Receptor - dependent and mitochondrial. The outsider apoptotic pathway is induced by external factors stimulating membrane receptors having an intracellular domain called death domain. Mitochondrial apoptotic pathway is activated by increased concentration of reactive oxygen species (ROS), DNA damage, disorders electrolyte transport and an increase in the concentration of the calcium ions in the cytoplasm. In response to stress-factors, mitochondrial channels are opened, so that is released into the cytoplasm cytochrome C. This work is aimed at an overall description of exchanged processes.