Levels of heavy metals and their binding protein
metallothionein in type 2 diabetics with kidney disease

J 2017

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

RAUDENSKÁ, Martina, Veronika DVOŘÁKOVÁ, Lukáš PÁCAL, Katarína CHALÁSOVÁ, Monika KRATOCHVÍLOVÁ et. al.

Basic information

Original name

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

Authors

RAUDENSKÁ, Martina (203 Czech Republic, guarantor, belonging to the institution), Veronika DVOŘÁKOVÁ (203 Czech Republic, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, belonging to the institution), Katarína CHALÁSOVÁ (703 Slovakia, belonging to the institution), Monika KRATOCHVÍLOVÁ (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), B. RUTTKAY-NEDECKY (203 Czech Republic), O. ZITKA (203 Czech Republic), Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution), V. ADAM (203 Czech Republic) and Michal MASAŘÍK (203 Czech Republic, belonging to the institution)

Edition

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, HOBOKEN, WILEY, 2017, 1095-6670

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.837

RIV identification code

RIV/00216224:14110/17:00094919

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/jbt.21891

UT WoS

000403147800009

Keywords in English

diabetes; diabetic kidney disease; heavy metals; metallothionein; oxidative stress

Abstract

V originále

Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.

Links

GA16-14829S, research and development project

Name: Efekt diabetického mikroprostředí na vybrané procesy při vzniku kolorektálního karcinomu, jeho klinický průběh a odpověď na terapii

Investor: Czech Science Foundation

Citovat

RAUDENSKÁ, Martina, Veronika DVOŘÁKOVÁ, Lukáš PÁCAL, Katarína CHALÁSOVÁ, Monika KRATOCHVÍLOVÁ, Jaromír GUMULEC, B. RUTTKAY-NEDECKY, O. ZITKA, Kateřina KAŇKOVÁ, V. ADAM and Michal MASAŘÍK. Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. HOBOKEN: WILEY, 2017, vol. 31, No 6, p. 1-5. ISSN 1095-6670. Available from: https://dx.doi.org/10.1002/jbt.21891.

@article{1388756,
   author = {Raudenská, Martina and Dvořáková, Veronika and Pácal, Lukáš and Chalásová, Katarína and Kratochvílová, Monika and Gumulec, Jaromír and RuttkayandNedecky, B. and Zitka, O. and Kaňková, Kateřina and Adam, V. and Masařík, Michal},
   article_location = {HOBOKEN},
   article_number = {6},
   doi = {http://dx.doi.org/10.1002/jbt.21891},
   keywords = {diabetes; diabetic kidney disease; heavy metals; metallothionein; oxidative stress},
   language = {eng},
   issn = {1095-6670},
   journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
   title = {Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease},
   volume = {31},
   year = {2017}
}

TY  - JOUR
ID  - 1388756
AU  - Raudenská, Martina - Dvořáková, Veronika - Pácal, Lukáš - Chalásová, Katarína - Kratochvílová, Monika - Gumulec, Jaromír - Ruttkay-Nedecky, B. - Zitka, O. - Kaňková, Kateřina - Adam, V. - Masařík, Michal
PY  - 2017
TI  - Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease
JF  - JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
VL  - 31
IS  - 6
SP  - 1-5
EP  - 1-5
PB  - WILEY
SN  - 10956670
KW  - diabetes
KW  - diabetic kidney disease
KW  - heavy metals
KW  - metallothionein
KW  - oxidative stress
N2  - Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.
ER  -

RAUDENSKÁ, Martina, Veronika DVOŘÁKOVÁ, Lukáš PÁCAL, Katarína CHALÁSOVÁ, Monika KRATOCHVÍLOVÁ, Jaromír GUMULEC, B. RUTTKAY-NEDECKY, O. ZITKA, Kateřina KAŇKOVÁ, V. ADAM and Michal MASAŘÍK. Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease. \textit{JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY}. HOBOKEN: WILEY, 2017, vol.~31, No~6, p.~1-5. ISSN~1095-6670. Available from: https://dx.doi.org/10.1002/jbt.21891.

Detailed Information on Publication Record