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@article{1388756,
author = {Raudenská, Martina and Dvořáková, Veronika and Pácal, Lukáš and Chalásová, Katarína and Kratochvílová, Monika and Gumulec, Jaromír and RuttkayandNedecky, B. and Zitka, O. and Kaňková, Kateřina and Adam, V. and Masařík, Michal},
article_location = {HOBOKEN},
article_number = {6},
doi = {http://dx.doi.org/10.1002/jbt.21891},
keywords = {diabetes; diabetic kidney disease; heavy metals; metallothionein; oxidative stress},
language = {eng},
issn = {1095-6670},
journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
title = {Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease},
volume = {31},
year = {2017}
}
TY - JOUR
ID - 1388756
AU - Raudenská, Martina - Dvořáková, Veronika - Pácal, Lukáš - Chalásová, Katarína - Kratochvílová, Monika - Gumulec, Jaromír - Ruttkay-Nedecky, B. - Zitka, O. - Kaňková, Kateřina - Adam, V. - Masařík, Michal
PY - 2017
TI - Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease
JF - JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
VL - 31
IS - 6
SP - 1-5
EP - 1-5
PB - WILEY
SN - 10956670
KW - diabetes
KW - diabetic kidney disease
KW - heavy metals
KW - metallothionein
KW - oxidative stress
N2 - Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.
ER -
RAUDENSKÁ, Martina, Veronika DVOŘÁKOVÁ, Lukáš PÁCAL, Katarína CHALÁSOVÁ, Monika KRATOCHVÍLOVÁ, Jaromír GUMULEC, B. RUTTKAY-NEDECKY, O. ZITKA, Kateřina KAŇKOVÁ, V. ADAM and Michal MASAŘÍK. Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease. \textit{JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY}. HOBOKEN: WILEY, 2017, vol.~31, No~6, p.~1-5. ISSN~1095-6670. Available from: https://dx.doi.org/10.1002/jbt.21891.
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