Detailed Information on Publication Record
2017
Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review
HLOUŠKOVÁ, Alena, Peter BIELIK, Ondřej BONCZEK, Vladimír Josef BALCAR, Omar ŠERÝ et. al.Basic information
Original name
Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review
Authors
HLOUŠKOVÁ, Alena (203 Czech Republic, belonging to the institution), Peter BIELIK (703 Slovakia, belonging to the institution), Ondřej BONCZEK (203 Czech Republic, belonging to the institution), Vladimír Josef BALCAR (36 Australia) and Omar ŠERÝ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Neuroendocrinology Letters, STOCKHOLM, MAGHIRA & MAAS PUBLICATIONS, 2017, 0172-780X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Sweden
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.754
RIV identification code
RIV/00216224:14310/17:00095658
Organization unit
Faculty of Science
UT WoS
000406690100001
Keywords in English
hypodontia; oligodontia; Wnt signal pathway; beta-catenine; tankyrase
Tags
International impact, Reviewed
Změněno: 9/4/2018 15:05, Ing. Nicole Zrilić
Abstract
V originále
AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer. These findings support the hypothesis that missing teeth may be a significant marker for predisposition for cancer.
Links
| NT11420, research and development project |
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