| HLOUŠKOVÁ, Alena, Peter BIELIK, Ondřej BONCZEK, Vladimír Josef BALCAR and Omar ŠERÝ. Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review. Neuroendocrinology Letters. STOCKHOLM: MAGHIRA & MAAS PUBLICATIONS, 2017, vol. 38, No 3, p. 131-137. ISSN 0172-780X. |
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@article{1389287,
author = {Hloušková, Alena and Bielik, Peter and Bonczek, Ondřej and Balcar, Vladimír Josef and Šerý, Omar},
article_location = {STOCKHOLM},
article_number = {3},
keywords = {hypodontia; oligodontia; Wnt signal pathway; beta-catenine; tankyrase},
language = {eng},
issn = {0172-780X},
journal = {Neuroendocrinology Letters},
title = {Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review},
volume = {38},
year = {2017}
}
TY - JOUR
ID - 1389287
AU - Hloušková, Alena - Bielik, Peter - Bonczek, Ondřej - Balcar, Vladimír Josef - Šerý, Omar
PY - 2017
TI - Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review
JF - Neuroendocrinology Letters
VL - 38
IS - 3
SP - 131-137
EP - 131-137
PB - MAGHIRA & MAAS PUBLICATIONS
SN - 0172780X
KW - hypodontia
KW - oligodontia
KW - Wnt signal pathway
KW - beta-catenine
KW - tankyrase
N2 - AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer. These findings support the hypothesis that missing teeth may be a significant marker for predisposition for cancer.
ER -
HLOUŠKOVÁ, Alena, Peter BIELIK, Ondřej BONCZEK, Vladimír Josef BALCAR and Omar ŠERÝ. Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review. \textit{Neuroendocrinology Letters}. STOCKHOLM: MAGHIRA \&{} MAAS PUBLICATIONS, 2017, vol.~38, No~3, p.~131-137. ISSN~0172-780X.
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