PUTNOVA, I., Hana DOSEDĚLOVÁ, Vítězslav BRYJA, Marie LANDOVÁ, marcela BUCHTOVÁ a Jan ŠTEMBÍREK. Angled Growth of the Dental Lamina Is Accompanied by Asymmetrical Expression of the WNT Pathway Receptor Frizzled 6. Frontiers in Physiology. Lausanne, SWITZERLAND: Frontiers Research Foundation, roč. 8, č. 29, s. 1-11. ISSN 1664-042X. doi:10.3389/fphys.2017.00029. 2017.
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Základní údaje
Originální název Angled Growth of the Dental Lamina Is Accompanied by Asymmetrical Expression of the WNT Pathway Receptor Frizzled 6
Autoři PUTNOVA, I. (203 Česká republika), Hana DOSEDĚLOVÁ (203 Česká republika), Vítězslav BRYJA (203 Česká republika, domácí), Marie LANDOVÁ (203 Česká republika), marcela BUCHTOVÁ (203 Česká republika, garant, domácí) a Jan ŠTEMBÍREK (203 Česká republika).
Vydání Frontiers in Physiology, Lausanne, SWITZERLAND, Frontiers Research Foundation, 2017, 1664-042X.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 10601 Cell biology
Stát vydavatele Švýcarsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 3.394
Kód RIV RIV/00216224:14310/17:00097547
Organizační jednotka Přírodovědecká fakulta
Doi http://dx.doi.org/10.3389/fphys.2017.00029
UT WoS 000392963400001
Klíčová slova anglicky FZD6; successional dental lamina; WNT signaling; planar cell polarity (PCP); odontoblast; ameloblast; osteoblast; epithelial remnants
Štítky NZ, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Nicole Zrilić, učo 240776. Změněno: 28. 3. 2018 15:52.
Anotace
Frizzled 6 (FZD6) belongs to a family of proteins that serve as receptors in the WNT signaling pathway. FZD6 plays an important role in the establishment of planar cell polarity in many embryonic processes such as convergent extension during gastrulation, neural tube closure, or hair patterning. Based on its role during hair development, we hypothesized that FZD6 may have similar expression pattern and function in the dental lamina, which is also a distinct epithelial protrusion growing characteristically angled into the mesenchyme. Diphyodont minipig was selected as a model species because its dentition closely resemble human ones with successional generation of teeth initiated from the dental lamina. We revealed asymmetrical expression of FZD6 in the dental lamina of early as well as late stages during its regression with stronger expression located on the labial side of the dental lamina. During lamina regression, FZD6-positive cells were found in its superficial part and the signal coincided with the upregulation of molecules involved in epithelial-mesenchymal transition and increased migratory potential of epithelial cells. FZD6-expression was also turned on during differentiation of cells producing hard tissues, in which mature odontoblasts, ameloblasts, or surrounding osteoblasts were FZD6-positive. On the other hand, the tip of successional lamina and its lingual part, in which progenitor cells are located, exhibited FZD6-negativity. In conclusion, asymmetrical expression of FZD6 correlates with the growth directionality and side-specific morphological differences in the dental lamina of diphyodont species. Based on observed expression pattern, we propose that the dental lamina is other epithelial tissue, where planar cell polarity signaling is involved during its asymmetrical growth.
Návaznosti
MUNI/A/0988/2016, interní kód MUNázev: Podpora výzkumné činnosti studentů v oblasti fyziologie a imunologie živočichů v roce 2017
Investor: Masarykova univerzita, Podpora výzkumné činnosti studentů v oblasti fyziologie a imunologie živočichů v roce 2017, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty
VytisknoutZobrazeno: 28. 3. 2024 09:42