J 2017

Synthesis of methyl 2-[(1,2-dihydro-4-hydroxy-2-oxo-1-phenylquinolin-3-yl) carbonylamino] alkanoates and methyl 2-[2-((1,2-dihydro-4-hydroxy-2-oxo-1- phenylquinolin-3-yl)carbonyl-amino)alkanamido] alkanoate

FATHALA, Walid Mohamed and Pavel PAZDERA

Basic information

Original name

Synthesis of methyl 2-[(1,2-dihydro-4-hydroxy-2-oxo-1-phenylquinolin-3-yl) carbonylamino] alkanoates and methyl 2-[2-((1,2-dihydro-4-hydroxy-2-oxo-1- phenylquinolin-3-yl)carbonyl-amino)alkanamido] alkanoate

Authors

FATHALA, Walid Mohamed (818 Egypt) and Pavel PAZDERA (203 Czech Republic, guarantor, belonging to the institution)

Edition

ARKIVOC, GAINESVILLE, USA, ARCAT-USA, 2017, 1551-7004

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10401 Organic chemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.048

RIV identification code

RIV/00216224:14310/17:00097589

Organization unit

Faculty of Science

DOI

UT WoS

000414746900014

Keywords in English

Amino acid esters; DCC coupling method; azide coupling method; direct amino acid condensation; anisotropy; intramolecular hydrogen bond interactions; linomide

Tags

Tags

International impact, Reviewed
Změněno: 12/4/2018 10:24, Ing. Nicole Zrilić

Abstract

V originále

A series of methyl 2-[(1,2-dihydro-4-hydroxy-2-oxo-1-phenylquinolin-3-yl)carbonylamino] alkanoates 7a-f has been developed by the direct condensation of ethyl [4-hydroxy-2-oxo--1-phenyl-1,2-dihydro-3-quinoline] carboxylate 4 with amino acid ester hydrochloride in the presence of triethylamine. The quinoline amino acid esters 7a-f were the key intermediate for the preparation of a series of methyl 2-[2-((1,2-dihydro-4-hydroxy-2- oxo-1-phenylquinolin-3-yl)carbonylamino)alkanamido] alkanoate 10-13(a-f) via azide coupling method with amino acid ester.