ŠMÍD, Petr, Martin KOMZÁK, Radek HART and Libor PAŠA. Mesenchymal stem cells in the reconstruction surgery of the supraspinatus muscle lesions. Clinical Investigation. London: Future Science, 2017, vol. 7, No 2, p. 103-110. ISSN 2041-6792.
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Basic information
Original name Mesenchymal stem cells in the reconstruction surgery of the supraspinatus muscle lesions
Authors ŠMÍD, Petr (203 Czech Republic, belonging to the institution), Martin KOMZÁK (203 Czech Republic), Radek HART (203 Czech Republic, guarantor) and Libor PAŠA (203 Czech Republic, belonging to the institution).
Edition Clinical Investigation, London, Future Science, 2017, 2041-6792.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30211 Orthopaedics
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/17:00097595
Organization unit Faculty of Medicine
Keywords in English Bone marrow stem cells; rotator cuff lesion
Tags EL OK
Tags Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 19/3/2018 13:51.
Abstract
The objective of the study was to demonstrate the effect of concentrated bone marrow stem cells (MSCs) to the healing of sutured tendon of the supraspinatus muscle in comparison to the same procedure performed without MSCs. We have postulated the hypothesis that MSCs enhance the healing of the sutured supraspinatus tendon to its humeral footprint. Methods and findings: None of the patients had to be excluded from our prospective randomized study. 50 patients met the indication criteria for isolated supraspinatus surgery. 25 patients (Group I) received MSCs into the supraspinatus footprint. 25 patients (Group II) was treated without the use of MSCs. Patients were examined pre-operatively, 6, 12 and 24 months after the surgery and assessment included physical examination, visual analogue scale (VAS), ASES (American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form) and Constant score. Patients underwent MRI 2 years postoperatively. Findings were compared with the preoperative results. We have found no statistically significant differences between both groups pre-operatively. After a 24-month follow-up period there were significant differences observed in all clinical outcomes. When compared results between both groups two years postoperatively, p-value (p=0.05) for the VAS score was 0.0176 and for the Constant score 0.0355. The only statistically non-significant was p-value for the ASES score comparing results from both groups at two years follow-up (p=0.085). The MRI findings at 2 years showed fully healed tissue of the rotator cuff tendon in 17 patients in the Group I, but only in 9 patients in the Group II. Conclusions: We have accepted the hypothesis that MSCs enhance the healing of the sutured supraspinatus tendon to its humeral footprint.
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