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@article{1390270,
author = {Stejskalova, Karla and Bayerová, Zuzana and Futas, Ján and Hrazdilová, Kristýna and Klumplerová, Marie and Oppelt, Jan and Splichalova, Petra and Guardo, Giovanni Di and Mazzariol, Sandro and Francesco, Cristina Esmeralda Di and Francesco, Gabriella Di and Terracciano, Giuliana and Paiu, RomulusandMarian and Ursache, Teodor Dan and Modry, David and Hořín, Petr},
article_number = {6},
doi = {http://dx.doi.org/10.1111/tan.13146},
keywords = {Cetacea; Immunity; innate; Haplotype; MHC-DQB; Phocoena phocoena; Polymorphism; single nucleotide; Stenella coeruleoalba},
language = {eng},
issn = {2059-2302},
journal = {HLA},
title = {Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans},
url = {http://dx.doi.org/10.1111/tan.13146},
volume = {90},
year = {2017}
}
TY - JOUR
ID - 1390270
AU - Stejskalova, Karla - Bayerová, Zuzana - Futas, Ján - Hrazdilová, Kristýna - Klumplerová, Marie - Oppelt, Jan - Splichalova, Petra - Guardo, Giovanni Di - Mazzariol, Sandro - Francesco, Cristina Esmeralda Di - Francesco, Gabriella Di - Terracciano, Giuliana - Paiu, Romulus-Marian - Ursache, Teodor Dan - Modry, David - Hořín, Petr
PY - 2017
TI - Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans
JF - HLA
VL - 90
IS - 6
SP - 343-353
EP - 343-353
SN - 20592302
KW - Cetacea
KW - Immunity
KW - innate
KW - Haplotype
KW - MHC-DQB
KW - Phocoena phocoena
KW - Polymorphism
KW - single nucleotide
KW - Stenella coeruleoalba
UR - http://dx.doi.org/10.1111/tan.13146
L2 - http://dx.doi.org/10.1111/tan.13146
N2 - Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Since free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced eleven candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena. Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin (BSG, CD147), the signaling lymphocyte activating molecule (SLAMF1), the poliovirus related receptor-4 (NECTIN4, PVRL4), toll-like receptors 3,7,8 (TLR3, TLR7, TLR8), natural resistance-associated macrophage protein (SLC11A1) and natural cytotoxicity triggering receptor 1 (NCR1), were identified in each model species, along with MHC-DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to Morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations.
ER -
STEJSKALOVA, Karla, Zuzana BAYEROVÁ, Ján FUTAS, Kristýna HRAZDILOVÁ, Marie KLUMPLEROVÁ, Jan OPPELT, Petra SPLICHALOVA, Giovanni Di GUARDO, Sandro MAZZARIOL, Cristina Esmeralda Di FRANCESCO, Gabriella Di FRANCESCO, Giuliana TERRACCIANO, Romulus-Marian PAIU, Teodor Dan URSACHE, David MODRY and Petr HOŘÍN. Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans. \textit{HLA}. 2017, vol.~90, No~6, p.~343-353. ISSN~2059-2302. Available from: https://dx.doi.org/10.1111/tan.13146.
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