Endocannabinoid system in sexual motivational processes: Is it
a novel therapeutic horizon?

J 2017

Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon?

ANDROVICOVA, R., J. HORACEK, Tibor ŠTARK, F. DRAGO, Vincenzo MICALE et. al.

Basic information

Original name

Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon?

Authors

ANDROVICOVA, R. (203 Czech Republic), J. HORACEK (203 Czech Republic), Tibor ŠTARK (703 Slovakia, guarantor, belonging to the institution), F. DRAGO (380 Italy) and Vincenzo MICALE (380 Italy, belonging to the institution)

Edition

PHARMACOLOGICAL RESEARCH, London, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017, 1043-6618

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.897

RIV identification code

RIV/00216224:14110/17:00097677

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.phrs.2016.11.021

UT WoS

000392790400018

Keywords in English

Endocannabinoids; Delta(9)-THC; Cannabinoid CB1 receptor; Sexual behavior

Abstract

V originále

The endocannabinoid system (ECS), which is composed of the cannabinoid receptors types 1 and 2 (CB1 and CB2) for marijuana's psychoactive ingredient Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the endogenous ligands (AEA and 2-AG) and the enzymatic systems involved in their biosynthesis and degradation, recently emerged as important modulator of emotional and non-emotional behaviors. For centuries, in addition to its recreational actions, several contradictory claims regarding the effects of Cannabis use in sexual functioning and behavior (e.g. aphrodisiac vs anti-aphrodisiac) of both sexes have been accumulated. The identification of Delta(9)-THC and later on, the discovery of the ECS have opened a potential therapeutic target for sexual dysfunctions, given the partial efficacy of current pharmacological treatment. In agreement with the bidirectional modulation induced by cannabinoids on several behavioral responses, the endogenous cannabinoid AEA elicited biphasic effects on sexual behavior as well. The present article reviews current available knowledge on herbal, synthetic and endogenous cannabinoids with respect to the modulation of several aspects of sexuality in preclinical and human studies, highlighting their therapeutic potential. (C) 2016 Elsevier Ltd. All rights reserved.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1284/2015, interní kód MU

Name: Experimentální farmakologický vývoj v neuropsychiatrii a onkologii

Investor: Masaryk University, Category A

Citovat

ANDROVICOVA, R., J. HORACEK, Tibor ŠTARK, F. DRAGO and Vincenzo MICALE. Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon? PHARMACOLOGICAL RESEARCH. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017, vol. 115, JAN 2017, p. 200-208. ISSN 1043-6618. Available from: https://dx.doi.org/10.1016/j.phrs.2016.11.021.

@article{1390704,
   author = {Androvicova, R. and Horacek, J. and Štark, Tibor and Drago, F. and Micale, Vincenzo},
   article_location = {London},
   article_number = {JAN 2017},
   doi = {http://dx.doi.org/10.1016/j.phrs.2016.11.021},
   keywords = {Endocannabinoids; Delta(9)-THC; Cannabinoid CB1 receptor; Sexual behavior},
   language = {eng},
   issn = {1043-6618},
   journal = {PHARMACOLOGICAL RESEARCH},
   title = {Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon?},
   volume = {115},
   year = {2017}
}

TY  - JOUR
ID  - 1390704
AU  - Androvicova, R. - Horacek, J. - Štark, Tibor - Drago, F. - Micale, Vincenzo
PY  - 2017
TI  - Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon?
JF  - PHARMACOLOGICAL RESEARCH
VL  - 115
IS  - JAN 2017
SP  - 200-208
EP  - 200-208
PB  - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN  - 10436618
KW  - Endocannabinoids
KW  - Delta(9)-THC
KW  - Cannabinoid CB1 receptor
KW  - Sexual behavior
N2  - The endocannabinoid system (ECS), which is composed of the cannabinoid receptors types 1 and 2 (CB1 and CB2) for marijuana's psychoactive ingredient Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the endogenous ligands (AEA and 2-AG) and the enzymatic systems involved in their biosynthesis and degradation, recently emerged as important modulator of emotional and non-emotional behaviors. For centuries, in addition to its recreational actions, several contradictory claims regarding the effects of Cannabis use in sexual functioning and behavior (e.g. aphrodisiac vs anti-aphrodisiac) of both sexes have been accumulated. The identification of Delta(9)-THC and later on, the discovery of the ECS have opened a potential therapeutic target for sexual dysfunctions, given the partial efficacy of current pharmacological treatment. In agreement with the bidirectional modulation induced by cannabinoids on several behavioral responses, the endogenous cannabinoid AEA elicited biphasic effects on sexual behavior as well. The present article reviews current available knowledge on herbal, synthetic and endogenous cannabinoids with respect to the modulation of several aspects of sexuality in preclinical and human studies, highlighting their therapeutic potential. (C) 2016 Elsevier Ltd. All rights reserved.
ER  -

ANDROVICOVA, R., J. HORACEK, Tibor ŠTARK, F. DRAGO and Vincenzo MICALE. Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon? \textit{PHARMACOLOGICAL RESEARCH}. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017, vol.~115, JAN 2017, p.~200-208. ISSN~1043-6618. Available from: https://dx.doi.org/10.1016/j.phrs.2016.11.021.

Detailed Information on Publication Record