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@article{1390704, author = {Androvicova, R. and Horacek, J. and Štark, Tibor and Drago, F. and Micale, Vincenzo}, article_location = {London}, article_number = {JAN 2017}, doi = {http://dx.doi.org/10.1016/j.phrs.2016.11.021}, keywords = {Endocannabinoids; Delta(9)-THC; Cannabinoid CB1 receptor; Sexual behavior}, language = {eng}, issn = {1043-6618}, journal = {PHARMACOLOGICAL RESEARCH}, title = {Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon?}, volume = {115}, year = {2017} }
TY - JOUR ID - 1390704 AU - Androvicova, R. - Horacek, J. - Štark, Tibor - Drago, F. - Micale, Vincenzo PY - 2017 TI - Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon? JF - PHARMACOLOGICAL RESEARCH VL - 115 IS - JAN 2017 SP - 200-208 EP - 200-208 PB - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD SN - 10436618 KW - Endocannabinoids KW - Delta(9)-THC KW - Cannabinoid CB1 receptor KW - Sexual behavior N2 - The endocannabinoid system (ECS), which is composed of the cannabinoid receptors types 1 and 2 (CB1 and CB2) for marijuana's psychoactive ingredient Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the endogenous ligands (AEA and 2-AG) and the enzymatic systems involved in their biosynthesis and degradation, recently emerged as important modulator of emotional and non-emotional behaviors. For centuries, in addition to its recreational actions, several contradictory claims regarding the effects of Cannabis use in sexual functioning and behavior (e.g. aphrodisiac vs anti-aphrodisiac) of both sexes have been accumulated. The identification of Delta(9)-THC and later on, the discovery of the ECS have opened a potential therapeutic target for sexual dysfunctions, given the partial efficacy of current pharmacological treatment. In agreement with the bidirectional modulation induced by cannabinoids on several behavioral responses, the endogenous cannabinoid AEA elicited biphasic effects on sexual behavior as well. The present article reviews current available knowledge on herbal, synthetic and endogenous cannabinoids with respect to the modulation of several aspects of sexuality in preclinical and human studies, highlighting their therapeutic potential. (C) 2016 Elsevier Ltd. All rights reserved. ER -
ANDROVICOVA, R., J. HORACEK, Tibor ŠTARK, F. DRAGO and Vincenzo MICALE. Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon? \textit{PHARMACOLOGICAL RESEARCH}. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017, vol.~115, JAN 2017, p.~200-208. ISSN~1043-6618. Available from: https://dx.doi.org/10.1016/j.phrs.2016.11.021.
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