2017
Relative efficacy and safety of ticagelor vs clopidogrel as a function of time to invasive management in non-ST-segment elevation acute coronary syndrome in the PLATO trial
POLLACK, C.V., F. DAVOUDI, D.B. DIERCKS, R.C. BECKER, S.K. JAMES et. al.Basic information
Original name
Relative efficacy and safety of ticagelor vs clopidogrel as a function of time to invasive management in non-ST-segment elevation acute coronary syndrome in the PLATO trial
Authors
POLLACK, C.V. (840 United States of America), F. DAVOUDI (840 United States of America), D.B. DIERCKS (840 United States of America), R.C. BECKER (840 United States of America), S.K. JAMES (752 Sweden), S.T. LIM (702 Singapore), P.J. SCHULTE (840 United States of America), Jindřich ŠPINAR (203 Czech Republic, guarantor, belonging to the institution), P.G. STEG (250 France), R.F. STOREY (840 United States of America), A. HIMMELMANN (752 Sweden), L. WALLENTIN (752 Sweden) and C.P. CANNON (840 United States of America)
Edition
Clinical Cardiology, Hoboken, John Wiley and Sons Inc. 2017, 0160-9289
Other information
Language
English
Type of outcome
Article in a journal
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
United States of America
Confidentiality degree
is not subject to a state or trade secret
Impact factor
Impact factor: 2.733
RIV identification code
RIV/00216224:14110/17:00097701
Organization unit
Faculty of Medicine
UT WoS
000405393200007
Keywords in English
Non-ST-Segment Elevation Acute Coronary Syndromes (NSTE-ACS); Antiplatelet Therapy; P2Y(12) Receptor Antagonists; Clopidogrel; Ticagrelor; Angiography
Tags
Tags
International impact, Reviewed
Changed: 13/3/2018 19:00, Soňa Böhmová
Abstract
V originále
Background: Guidelines suggest that "upstream" P2Y(12) receptor antagonists should be considered in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). Hypothesis: Early use of ticagrelor in patients managed with an invasive strategy would be more effective than clopidogrel because of its more rapid onset of action and greater potency. Methods: In the PLATO trial, 6792 NSTE-ACS patients were randomized to ticagrelor or clopidogrel (started prior to angiography) and underwent angiography within 72 hours of randomization. We compared efficacy and safety outcomes of ticagrelor vs clopidogrel as a function of "early" (<3h) vs "late" (>= 3h) time to angiography. Adjusted Cox proportional hazards models evaluated interaction between randomized treatment and time from randomization to angiography on subsequent outcomes. Results: Overall, a benefit of ticagrelor vs clopidogrel for cardiovascular death/myocardial infarction/stroke was seen at day 7 (hazard ratio [HR]: 0.67, P = 0.002), day 30 (HR: 0.81, P = 0.042), and 1 year (HR: 0.80, P = 0.0045). There were no significant interactions in the <3h vs >= 3h groups at any timepoint. For major bleeding, overall there was no significant increase (HR: 1.04, 95% confidence interval: 0.85-1.27); but there was a significant interaction with no difference between ticagrelor and clopidogrel in the early group (HR: 0.79), but higher bleeding risk with ticagrelor in the late angiography group, at 7 days (HR: 1.51, P-int = 0.002). Patterns were similar at 30 days and 1 year. Conclusions: The benefit of ticagrelor over clopidogrel was consistent in those undergoing early and late angiography, supporting upstream use of ticagrelor