Minimal residual disease assessment in multiple myeloma by
multiparametric flow cytometry

J 2017

Minimal residual disease assessment in multiple myeloma by multiparametric flow cytometry

RIHOVA, L., Pavla VŠIANSKÁ, Renata BEZDĚKOVÁ, Romana KRÁLOVÁ, Miroslav PENKA et. al.

Basic information

Original name

Minimal residual disease assessment in multiple myeloma by multiparametric flow cytometry

Name in Czech

Analýza minimální reziduální nemoci u mnohočetného myelomu pomocí multiparametrické průtokové cytometrie

Authors

RIHOVA, L. (203 Czech Republic, guarantor), Pavla VŠIANSKÁ (203 Czech Republic), Renata BEZDĚKOVÁ (203 Czech Republic), Romana KRÁLOVÁ (203 Czech Republic), Miroslav PENKA (203 Czech Republic), Marta KREJČÍ (203 Czech Republic, belonging to the institution), Luděk POUR (203 Czech Republic, belonging to the institution) and R. HAJEK (203 Czech Republic)

Edition

Klinická onkologie, Praha, Ambit Media, 2017, 0862-495X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/17:00097851

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.14735/amko20172S21

Keywords in English

flow cytometry; minimal residual disease; multiple myeloma; plasma cells

Abstract

V originále

Background: Progress in treatment of multiple myeloma extensively increased patient remission rates, so minimal residual disease (MRD) detection becomes essential to assess the effectivity of treatment and depth of complete response. Nowadays, multiparametric flow cytometry(MFC) is the most used method for monitoring of MRD presence in the bone marrow of multiple myeloma patients; however, detection on molecular level can be used as well. It is evident that choice of protocol used for MFC-MRD assessment can significantly affect required results;nevertheless, standardized and highly sensitive approach of "next generation flow" is already available. Although benefit of MRD assessment as an independent predictor of progression- -free survival and over all survival is known, very recent research showed that MRD-negative status surpasses the prognostic value of complete response achievement for progression-free survival and over all survival. Aim: This review is focused on use MFC in MRD assessment in multiple myeloma. The technical aspects and clinical benefits of this approach are mentioned as well. Conclusion: The information about MRD level detected by highly sensitive and reproducible MFC can be potentially used as a bio marker to evaluate the efficacy of different treatment strategies, help on treatment decisions and act as a surrogate for over all survival in multiple myeloma patients.

Citovat

RIHOVA, L., Pavla VŠIANSKÁ, Renata BEZDĚKOVÁ, Romana KRÁLOVÁ, Miroslav PENKA, Marta KREJČÍ, Luděk POUR and R. HAJEK. Minimal residual disease assessment in multiple myeloma by multiparametric flow cytometry. Klinická onkologie. Praha: Ambit Media, 2017, vol. 30, Suppl. 2, p. "2S21"-"2S28", 8 pp. ISSN 0862-495X. Available from: https://dx.doi.org/10.14735/amko20172S21.

@article{1392118,
   author = {Rihova, L. and Všianská, Pavla and Bezděková, Renata and Králová, Romana and Penka, Miroslav and Krejčí, Marta and Pour, Luděk and Hajek, R.},
   article_location = {Praha},
   article_number = {Suppl. 2},
   doi = {http://dx.doi.org/10.14735/amko20172S21},
   keywords = {flow cytometry; minimal residual disease; multiple myeloma; plasma cells},
   language = {eng},
   issn = {0862-495X},
   journal = {Klinická onkologie},
   title = {Minimal residual disease assessment in multiple myeloma by multiparametric flow cytometry},
   volume = {30},
   year = {2017}
}

TY  - JOUR
ID  - 1392118
AU  - Rihova, L. - Všianská, Pavla - Bezděková, Renata - Králová, Romana - Penka, Miroslav - Krejčí, Marta - Pour, Luděk - Hajek, R.
PY  - 2017
TI  - Minimal residual disease assessment in multiple myeloma by multiparametric flow cytometry
JF  - Klinická onkologie
VL  - 30
IS  - Suppl. 2
SP  - "2S21"-"2S28"
EP  - "2S21"-"2S28"
PB  - Ambit Media
SN  - 0862495X
KW  - flow cytometry
KW  - minimal residual disease
KW  - multiple myeloma
KW  - plasma cells
N2  - Background: Progress in treatment of multiple myeloma extensively increased patient remission rates, so minimal residual disease (MRD) detection becomes essential to assess the effectivity of treatment and depth of complete response. Nowadays, multiparametric flow cytometry(MFC) is the most used method for monitoring of MRD presence in the bone marrow of multiple myeloma patients; however, detection on molecular level can be used as well. It is evident that choice of protocol used for MFC-MRD assessment can significantly affect required results;nevertheless, standardized and highly sensitive approach of "next generation flow" is already available. Although benefit of MRD assessment as an independent predictor of progression- -free survival and over all survival is known, very recent research showed that MRD-negative status surpasses the prognostic value of complete response achievement for progression-free survival and over all survival. Aim: This review is focused on use MFC in MRD assessment in multiple myeloma. The technical aspects and clinical benefits of this approach are mentioned as well. Conclusion: The information about MRD level detected by highly sensitive and reproducible MFC can be potentially used as a bio marker to evaluate the efficacy of different treatment strategies, help on treatment decisions and act as a surrogate for over all survival in multiple myeloma patients.
ER  -

RIHOVA, L., Pavla VŠIANSKÁ, Renata BEZDĚKOVÁ, Romana KRÁLOVÁ, Miroslav PENKA, Marta KREJČÍ, Luděk POUR and R. HAJEK. Minimal residual disease assessment in multiple myeloma by multiparametric flow cytometry. \textit{Klinická onkologie}. Praha: Ambit Media, 2017, vol.~30, Suppl. 2, p.~''2S21''-''2S28'', 8 pp. ISSN~0862-495X. Available from: https://dx.doi.org/10.14735/amko20172S21.

Detailed Information on Publication Record