Biobanking – the First Step to Successful Liquid Biopsy
Experiments

J 2017

Biobanking – the First Step to Successful Liquid Biopsy Experiments

ALMÁŠI, Martina, Sabina ŠEVČÍKOVÁ, Miroslav PENKA, Marta KREJČÍ, Zdeněk ADAM et. al.

Basic information

Original name

Biobanking – the First Step to Successful Liquid Biopsy Experiments

Authors

ALMÁŠI, Martina (203 Czech Republic), Sabina ŠEVČÍKOVÁ (203 Czech Republic, belonging to the institution), Miroslav PENKA (203 Czech Republic), Marta KREJČÍ (203 Czech Republic), Zdeněk ADAM (203 Czech Republic), P. VRUBLOVA (203 Czech Republic), T. JELINEK (203 Czech Republic) and R. HAJEK (203 Czech Republic)

Edition

Klinická onkologie, Praha, Ambit Media, 2017, 0862-495X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/17:00097853

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.14735/amko20172S9

Keywords in English

archiving; biological material; informed consent; multiple myeloma; plasma cells; biobanking

Abstract

V originále

Archiving of biological materials in biobanks is considered to be the initial crucial part of research activities. Most often, biobanks are founded for research purposes since they allow collection of sufficient material for analysis of new or testing of previously identified biomarkers. Biobanking needs to quickly react to current needs of researchers as well as clinicians, it is not a rigid system. Laboratory analyses of monoclonal gammopathies are based on separation of plasma cells from bone marrow of patients. A specific problem is usually a lack of tumor cell fraction, which is due to location of tumor cell in bone marrow in combination with low infiltration. One of the challenges in clinical research is the necessity of changes in biobanking for samples allowing detection of minimal residual disease in the bone marrow but also from peripheral blood by the so-called liquid biopsies. Aim: The aim of this review is to show the importance of archiving biological material in the Czech Republic and to show concrete examples of its usage in hematooncology. Conclusion: A general problem in solving many research questions is the availability of a critical amount of specimens for statistical analysis. Obtaining critical amount of specimens of biological material can be quickly archived by cooperation of biobanks sharing both methodological standards and informations about the availability of samples for research projects.

Citovat

ALMÁŠI, Martina, Sabina ŠEVČÍKOVÁ, Miroslav PENKA, Marta KREJČÍ, Zdeněk ADAM, P. VRUBLOVA, T. JELINEK and R. HAJEK. Biobanking – the First Step to Successful Liquid Biopsy Experiments. Klinická onkologie. Praha: Ambit Media, 2017, vol. 30, Suppl. 2, p. "2S9"-"2S12", 4 pp. ISSN 0862-495X. Available from: https://dx.doi.org/10.14735/amko20172S9.

@article{1392127,
   author = {Almáši, Martina and Ševčíková, Sabina and Penka, Miroslav and Krejčí, Marta and Adam, Zdeněk and Vrublova, P. and Jelinek, T. and Hajek, R.},
   article_location = {Praha},
   article_number = {Suppl. 2},
   doi = {http://dx.doi.org/10.14735/amko20172S9},
   keywords = {archiving; biological material; informed consent; multiple myeloma; plasma cells; biobanking},
   language = {eng},
   issn = {0862-495X},
   journal = {Klinická onkologie},
   title = {Biobanking – the First Step to Successful Liquid Biopsy Experiments},
   volume = {30},
   year = {2017}
}

TY  - JOUR
ID  - 1392127
AU  - Almáši, Martina - Ševčíková, Sabina - Penka, Miroslav - Krejčí, Marta - Adam, Zdeněk - Vrublova, P. - Jelinek, T. - Hajek, R.
PY  - 2017
TI  - Biobanking – the First Step to Successful Liquid Biopsy Experiments
JF  - Klinická onkologie
VL  - 30
IS  - Suppl. 2
SP  - "2S9"-"2S12"
EP  - "2S9"-"2S12"
PB  - Ambit Media
SN  - 0862495X
KW  - archiving
KW  - biological material
KW  - informed consent
KW  - multiple myeloma
KW  - plasma cells
KW  - biobanking
N2  - Archiving of biological materials in biobanks is considered to be the initial crucial part of research activities. Most often, biobanks are founded for research purposes since they allow collection of sufficient material for analysis of new or testing of previously identified biomarkers. Biobanking needs to quickly react to current needs of researchers as well as clinicians, it is not a rigid system. Laboratory analyses of monoclonal gammopathies are based on separation of plasma cells from bone marrow of patients. A specific problem is usually a lack of tumor cell fraction, which is due to location of tumor cell in bone marrow in combination with low infiltration. One of the challenges in clinical research is the necessity of changes in biobanking for samples allowing detection of minimal residual disease in the bone marrow but also from peripheral blood by the so-called liquid biopsies. Aim: The aim of this review is to show the importance of archiving biological material in the Czech Republic and to show concrete examples of its usage in hematooncology. Conclusion: A general problem in solving many research questions is the availability of a critical amount of specimens for statistical analysis. Obtaining critical amount of specimens of biological material can be quickly archived by cooperation of biobanks sharing both methodological standards and informations about the availability of samples for research projects.
ER  -

ALMÁŠI, Martina, Sabina ŠEVČÍKOVÁ, Miroslav PENKA, Marta KREJČÍ, Zdeněk ADAM, P. VRUBLOVA, T. JELINEK and R. HAJEK. Biobanking – the First Step to Successful Liquid Biopsy Experiments. \textit{Klinická onkologie}. Praha: Ambit Media, 2017, vol.~30, Suppl. 2, p.~''2S9''-''2S12'', 4 pp. ISSN~0862-495X. Available from: https://dx.doi.org/10.14735/amko20172S9.

Detailed Information on Publication Record