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@article{1392128, author = {Kubaczková, Veronika and Vrábel, Dávid and Sedlaříková, Lenka and Bešše, Lenka and Ševčíková, Sabina}, article_location = {Hoboken}, article_number = {4}, doi = {http://dx.doi.org/10.1111/ejh.12925}, keywords = {acute lymphoblastic leukemia; acute myeloid leukemia; multiple myeloma; myelodysplastic syndromes}, language = {eng}, issn = {0902-4441}, journal = {European Journal of Haematology}, title = {Cell-free DNA — Minimally invasive marker of hematological malignancies}, volume = {99}, year = {2017} }
TY - JOUR ID - 1392128 AU - Kubaczková, Veronika - Vrábel, Dávid - Sedlaříková, Lenka - Bešše, Lenka - Ševčíková, Sabina PY - 2017 TI - Cell-free DNA — Minimally invasive marker of hematological malignancies JF - European Journal of Haematology VL - 99 IS - 4 SP - 291-299 EP - 291-299 PB - Wiley SN - 09024441 KW - acute lymphoblastic leukemia KW - acute myeloid leukemia KW - multiple myeloma KW - myelodysplastic syndromes N2 - Although tumor cells are the most reliable source of tumor DNA, biopsy of the tumor is an invasive procedure that should be avoided in some cases. The main limitation of any biopsy is sampling of one tumor site, which may not represent all malignant clones due to the heterogeneity of the tumor. These clones respond to treatment differently and thus directly influence survival of the patient. Circulating cell-free DNA (cfDNA) is released from multiple tumor sites, reflects overall heterogeneity of the tumor, and correlates with its progression. Detection of tumor-specific genetic and epigenetic aberrations in cfDNA could have a direct impact on molecular diagnosis, prognosis, follow-up of disease, monitoring of minimal residual disease, and response to treatment. While most cfDNA data are still experimental, they are very promising. This review focuses on cfDNA in hematological malignancies. ER -
KUBACZKOVÁ, Veronika, Dávid VRÁBEL, Lenka SEDLAŘÍKOVÁ, Lenka BEŠŠE and Sabina ŠEVČÍKOVÁ. Cell-free DNA — Minimally invasive marker of hematological malignancies. \textit{European Journal of Haematology}. Hoboken: Wiley, 2017, vol.~99, No~4, p.~291-299. ISSN~0902-4441. Available from: https://dx.doi.org/10.1111/ejh.12925.
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