Detailed Information on Publication Record
2018
Haloperidol Affects Plasticity of Differentiated NG-108 Cells Through sigma 1R/IP(3)R1 Complex
KUBICKOVA, J., L. LENCESOVA, L. CSADEROVA, Tibor STRAČINA, S. HUDECOVA et. al.Basic information
Original name
Haloperidol Affects Plasticity of Differentiated NG-108 Cells Through sigma 1R/IP(3)R1 Complex
Authors
KUBICKOVA, J. (703 Slovakia), L. LENCESOVA (703 Slovakia), L. CSADEROVA (703 Slovakia), Tibor STRAČINA (703 Slovakia, belonging to the institution), S. HUDECOVA (703 Slovakia), Petr BABULA (203 Czech Republic, belonging to the institution), E. ROZBORILOVA (703 Slovakia), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Oľga KRIŽANOVÁ (703 Slovakia, guarantor, belonging to the institution)
Edition
Cellular and Molecular Neurobiology, New York, Springer/Plenum Publishers, 2018, 0272-4340
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10601 Cell biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.811
RIV identification code
RIV/00216224:14110/18:00102078
Organization unit
Faculty of Medicine
UT WoS
000423033800017
Keywords in English
BD 1047; Haloperidol; Sigma 1 receptor; Dopamine 2 receptor
Tags
International impact, Reviewed
Změněno: 10/2/2019 13:19, Soňa Böhmová
Abstract
V originále
Haloperidol is an antipsychotic agent that primarily acts as an antagonist of D2 dopamine receptors. Besides other receptor systems, it targets sigma 1 receptors (sigma 1Rs) and inositol 1,4,5-trisphosphate receptors (IP(3)Rs). Aim of this work was to investigate possible changes in IP(3)Rs and sigma 1Rs resulting from haloperidol treatment and to propose physiological consequences in differentiated NG-108 cells, i.e., effect on cellular plasticity. Haloperidol treatment resulted in up-regulation of both type 1 IP(3)Rs (IP(3)R1s) and sigma 1Rs at mRNA and protein levels. Haloperidol treatment did not alter expression of other types of IP(3)Rs. Calcium release from endoplasmic reticulum (ER) mediated by increased amount of IP(3)R1s elevated cytosolic calcium and generated ER stress. IP(3)R1s were bound to sigma 1Rs, and translocation of this complex from ER to nucleus occurred in the group of cells treated with haloperidol, which was followed by increased nuclear calcium levels. Haloperidol-induced changes in cytosolic, reticular, and nuclear calcium levels were similar when specific sigma 1 blocker -BD 1047- was used. Changes in calcium levels in nucleus, ER, and cytoplasm might be responsible for alterations in cellular plasticity, because length of neurites increased and number of neurites decreased in haloperidol-treated differentiated NG-108 cells.
Links
| MUNI/A/1355/2016, interní kód MU |
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