Detailed Information on Publication Record
2017
A Concise Synthesis of Forskolin
HYLSE, Ondřej, Lukáš MAIER, Roman KUČERA, Tomáš PEREČKO, Aneta SVOBODOVÁ et. al.Basic information
Original name
A Concise Synthesis of Forskolin
Authors
HYLSE, Ondřej (203 Czech Republic, belonging to the institution), Lukáš MAIER (203 Czech Republic, belonging to the institution), Roman KUČERA (703 Slovakia, belonging to the institution), Tomáš PEREČKO (703 Slovakia), Aneta SVOBODOVÁ (203 Czech Republic), Lukáš KUBALA (203 Czech Republic), Kamil PARUCH (203 Czech Republic, guarantor, belonging to the institution) and Jakub ŠVENDA (203 Czech Republic, belonging to the institution)
Edition
Angewandte Chemie International Edition, Německo, Verlag Chemie, 2017, 1433-7851
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10401 Organic chemistry
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 12.102
RIV identification code
RIV/00216224:14310/17:00097892
Organization unit
Faculty of Science
UT WoS
000411810600029
Keywords in English
adenylyl cyclases; forskolin; natural product synthesis; structural analogues
Tags
Tags
International impact, Reviewed
Změněno: 10/5/2019 09:02, Mgr. Jakub Švenda, PhD.
Abstract
V originále
A 24-step synthesis of (:)-forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly of a sterically encumbered isoxazole ring, and c) citric acidmodified Upjohn dihydroxylation of a resilient tetrasubstituted olefin. The developed route has exciting potential for the preparation of new forskolin analogues inaccessible by semisynthesis.
Links
| GJ15-10504Y, research and development project |
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| LM2015043, research and development project |
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| LM2015063, research and development project |
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| MUNI/E/0104/2017, interní kód MU |
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